Multifunctional Silver Nanoparticles-Decorated Silica Functionalized with Retinoic Acid with Anti-Proliferative and Antimicrobial Properties

被引：4

作者：

Tudose, Madalina ^{[1
]}

Culita, Daniela C. ^{[1
]}

Musuc, Adina M. ^{[1
]}

Marinescu, Gabriela ^{[1
]}

Somacescu, Simona ^{[1
]}

Munteanu, Cornel ^{[1
]}

Bleotu, Coralia ^{[2
]}

Chifiriuc, Mariana C. ^{[3
,4
]}

机构：

[1] Romanian Acad, Inst Phys Chem Ilie Murgulescu, Bucharest 060021, Romania

[2] St S Nicolau Virol Inst, 285 Mihai Bravu Ave,Sect 3,77,POB 201, Bucharest 030304, Romania

[3] Univ Bucharest, Fac Biol, Dept Microbiol Immunol, Aleea Portocalelor 1-3, Bucharest, Romania

[4] Univ Bucharest, Res Inst, Spl Independentei 91-95, Bucharest, Romania

来源：

JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS | 2016年 / 26卷 / 05期

关键词：

Composites; Retinoic acid; Chemical synthesis; Transmission electron microscopy; Thermogravimetric analysis; GRAM-NEGATIVE BACTERIA; CELL-LINES; ALL-TRANS; GROWTH; DIFFERENTIATION; STIMULATION; AGENTS; DEATH;

D O I：

10.1007/s10904-016-0407-6

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The paper describes a rapid and simple method for preparing a multifunctional biomaterial based on retinoic acid covalently bound on silica@Ag particles. Monodispersed SiO2 particles were prepared by Stober method and further used for loading the Ag nanoparticles on their surface. This composite was further functionalized with retinoic acid. Characterization of the hybrid materials was made by UV-Visible spectroscopy, Transmission electron microscopy, Scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and Thermal analysis. The biological evaluation of the obtained materials revealed their potential use for multiple biomedical applications, from anti-proliferative agents to novel antimicrobial and antibiofilm strategies.

引用

页码：1043 / 1052

页数：10

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