Eumycetoma caused by Cladophialophora bantiana successfully treated with itraconazole

被引：15

作者：

Bonifaz, Alexandro ^{[1
,2
]}

De Hoog, Sybren ^{[3
]}

McGinnis, Michael R. ^{[4
]}

Saul, Amado ^{[1
,2
]}

Rodriguez-Cortes, Octavio ^{[1
,2
]}

Araiza, Javier ^{[1
,2
]}

Cruz, Mariana ^{[1
,2
]}

Mercadillo, Patricia ^{[1
]}

机构：

[1] Gen Hosp Mexico, Dermatol Serv, Del Valle, Mexico

[2] Gen Hosp Mexico, Dept Mycol, Del Valle, Mexico

[3] Cent Bur Schimmelcultures, Utrecht, Netherlands

[4] Univ Texas Med Branch, Dept Pathol, Galveston, TX USA

来源：

MEDICAL MYCOLOGY | 2009年 / 47卷 / 01期

关键词：

Eumycetoma; mycetoma; Cladophialophora bantiana; itraconazole; phaeohyphomycosis; PHEOHYPHOMYCOSIS; MYCETOMA; THERAPY;

D O I：

10.1080/13693780802430639

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A 57-year-old male presented with dermatosis of the dorsum of the foot consisting of tumefaction, deformity and sinus tract formation. The direct examination of exudates as well as the biopsy tissue, demonstrated the presence of black granules. A dematiaceous fungus was isolated from the lesions and was identified by ribosomal DNA sequencing as Cladophialophora bantiana. This is the second report of this fungus as an etiologic agent of eumycetoma in humans. Clinical and mycologic cure was achieved after 20 months of treatment with itraconazole at a starting dose of 300 mg/day that was tapered during the course of therapy. The patient's isolate had an itraconazole MIC of 0.012g/ml.

引用

页码：111 / 114

页数：4

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