Anti-angiogenic activity of rPAI-123 and vasa vasorum regression

被引：3

作者：

Mulligan-Kehoe, Mary Jo ^{[1
]}

机构：

[1] Geisel Sch Med Dartmouth, Dept Surg, Vasc Sect, Lebanon, NH 03756 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2013年 / 23卷 / 04期

关键词：

ENDOTHELIAL GROWTH-FACTOR; ATHEROSCLEROTIC PLAQUE PROGRESSION; E-DEFICIENT MICE; CORONARY-ARTERIES; EXPERIMENTAL HYPERCHOLESTEROLEMIA; MATRIX METALLOPROTEINASES; VASCULAR-PERMEABILITY; EXTRACELLULAR-MATRIX; INTIMAL HYPERPLASIA; COLLAGEN MATRICES;

D O I：

10.1016/j.tcm.2012.09.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The vasa vasorum are unique networks of vessels that become angiogenic in response to changes in the vessel wall. Structural studies, using various imaging modalities, show that the vasa vasorum form a plexus of microvessels during the atherosclerotic disease process. The events that stimulate vasa vasorum neovascularization remain unclear. Anti-angiogenic molecules have been shown to inhibit/regress the neovascularization; they provide significant insight into vasa vasorum function, structure, and specific requirements for growth and stability. This review discusses evidence for and against potential stimulators of vasa vasorum neovascularization. Anti-angiogenic rPAI-1(23), a truncated isoform of plasminogen activator inhibitor-1 (PAI-1) stimulates a novel pathway for regulating plasmin activity. This mechanism contributes significantly to vasa vasorum regression/collapse and is discussed as a model of regression. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：114 / 120

页数：7

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