Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat

被引：261
作者：
Gauguier, D
Froguel, P
Parent, V
Bernard, C
Bihoreau, MT
Portha, B
James, MR
Penicaud, L
Lathrop, M
Ktorza, A
机构：
[1] ST LOUIS HOSP,INSERM,U358,F-75010 PARIS,FRANCE
[2] INST PASTEUR,CNRS,EP 10,F-59019 LILLE,FRANCE
[3] UNIV PARIS 07,PHYSIOPATHOL NUTR LAB,CNRS,URA 307,F-75005 PARIS,FRANCE
来源：
NATURE GENETICS | 1996年 / 12卷 / 01期
基金：
英国惠康基金;
关键词：
D O I：
10.1038/ng0196-38
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Goto-Kakizaki (GK) rats are a well characterized model for non-insulin dependent diabetes mellitus (NIDDM). We have used a combination of physiological and genetic studies to identify quantitative trait loci (QTLs) responsible for the control of glucose homeostasis and insulin secretion in a F-2 cohort bred from spontaneously diabetic GK rats. The genetic dissection of NIDDM allowed us to map up to six independently segregating loci predisposing to hyperglycaemia, glucose intolerance or altered insulin secretion, and a seventh locus implicated in body weight. QTLs implicated in glucose tolerance and adiposity map to the same region of rat chromosome 1, and may indicate the influence of a single locus. Our study demonstrates that distinct combinations of genetic loci are responsible for different physiological characteristics associated with the diabetic phenotype in the GK rat, and it constitutes an important step for directing the search for the genetic factors involved in human NIDDM.
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收藏
页码：38 / 43
页数：6
相关论文
共 35 条
[1]  
ABDELHALIM SM, 1994, DIABETES, V43, P2811
[2]   SPECIFIC-INHIBITION OF ENDOGENOUS NEUROPEPTIDE-Y SYNTHESIS IN ARCUATE NUCLEUS BY ANTISENSE OLIGONUCLEOTIDES SUPPRESSES FEEDING-BEHAVIOR AND INSULIN-SECRETION [J].
AKABAYASHI, A ;
WAHLESTEDT, C ;
ALEXANDER, JT ;
LEIBOWITZ, SF .
MOLECULAR BRAIN RESEARCH, 1994, 21 (1-2) :55-61
[3]   GENETIC-MAPPING OF QUANTITATIVE TRAIT LOCI FOR GROWTH AND FATNESS IN PIGS [J].
ANDERSSON, L ;
HALEY, CS ;
ELLEGREN, H ;
KNOTT, SA ;
JOHANSSON, M ;
ANDERSSON, K ;
ANDERSSONEKLUND, L ;
EDFORSLILJA, I ;
FREDHOLM, M ;
HANSSON, I ;
HAKANSSON, J ;
LUNDSTROM, K .
SCIENCE, 1994, 263 (5154) :1771-1774
[4]   MATERNALLY TRANSMITTED DIABETES AND DEAFNESS ASSOCIATED WITH A 10.4 KB MITOCHONDRIAL-DNA DELETION [J].
BALLINGER, SW ;
SHOFFNER, JM ;
HEDAYA, EV ;
TROUNCE, I ;
POLAK, MA ;
KOONTZ, DA ;
WALLACE, DC .
NATURE GENETICS, 1992, 1 (01) :11-15
[5]   DIABETES IN IDENTICAL-TWINS - A STUDY OF 200 PAIRS [J].
BARNETT, AH ;
EFF, C ;
LESLIE, RDG ;
PYKE, DA .
DIABETOLOGIA, 1981, 20 (02) :87-93
[6]  
COOK DL, 1992, INT TXB DIABETES MEL, P89
[7]   INSULIN-LIKE GROWTH FACTOR-I AND FACTOR-II - PEPTIDE, MESSENGER RIBONUCLEIC-ACID AND GENE STRUCTURES, SERUM, AND TISSUE CONCENTRATIONS [J].
DAUGHADAY, WH ;
ROTWEIN, P .
ENDOCRINE REVIEWS, 1989, 10 (01) :68-91
[8]   COSEGREGATION OF BLOOD-PRESSURE WITH ANGIOTENSIN CONVERTING ENZYME AND ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR GENES USING DAHL SALT-SENSITIVE RATS [J].
DENG, YL ;
RAPP, JP .
NATURE GENETICS, 1992, 1 (04) :267-272
[9]   GENETIC-DETERMINANTS OF DIASTOLIC AND PULSE PRESSURE MAP TO DIFFERENT LOCI IN LYON HYPERTENSIVE RATS [J].
DUBAY, C ;
VINCENT, M ;
SAMANI, NJ ;
HILBERT, P ;
KAISER, MA ;
BERESSI, JP ;
KOTELEVTSEV, Y ;
BECKMANN, JS ;
SOUBRIER, F ;
SASSARD, J ;
LATHROP, GM .
NATURE GENETICS, 1993, 3 (04) :354-357
[10]   CLOSE LINKAGE OF GLUCOKINASE LOCUS ON CHROMOSOME-7P TO EARLY-ONSET NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].
FROGUEL, P ;
VAXILLAIRE, M ;
SUN, F ;
VELHO, G ;
ZOUALI, H ;
BUTEL, MO ;
LESAGE, S ;
VIONNET, N ;
CLEMENT, K ;
FOUGEROUSSE, F ;
TANIZAWA, Y ;
WEISSENBACH, J ;
BECKMANN, JS ;
LATHROP, GM ;
PASSA, P ;
PERMUTT, MA ;
COHEN, D .
NATURE, 1992, 356 (6365) :162-164
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