Fluorescent chemosensor for biological zinc ions

被引:9
|
作者
Bae, Se Won [1 ]
Kim, Eunha [1 ,2 ]
Shin, Ik-Soo [1 ,3 ]
Park, Seung Bum [1 ,2 ]
Hong, Jong-In [1 ]
机构
[1] Seoul Natl Univ, Dept Chem, Seoul 151747, South Korea
[2] Seoul Natl Univ, Dept Biophys & Chem Biol, BioMAX Inst, Seoul 151747, South Korea
[3] Soongsil Univ, Dept Chem, Seoul 156743, South Korea
关键词
fluorescent sensor; zinc ion; PeT; cell imaging; MOBILE ZINC; SENSOR; RECOGNITION; APOPTOSIS; SWITCHES; HEALTH; CELLS;
D O I
10.1080/10610278.2012.720020
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A synthetic fluorescent sensor (sensor 1) is developed using boron-dipyrromethene as a fluorophore and phenoxo-bridged dipicolylamine as a receptor. Sensor 1 shows a significant enhancement of fluorescent intensity and a high selectivity for Zn2+ over various metal cations. The electrochemical study provides a rationale for the fluorescence turn-on of sensor 1 upon complexation with Zn2+ by the blocking of the photo-induced electron transfer mechanism. Sensor 1 can be used to image Zn2+ in A549 cells.
引用
收藏
页码:2 / 6
页数:5
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