Fluorescent chemosensor for biological zinc ions

被引：9

作者：

Bae, Se Won ^{[1
]}

Kim, Eunha ^{[1
,2
]}

Shin, Ik-Soo ^{[1
,3
]}

Park, Seung Bum ^{[1
,2
]}

Hong, Jong-In ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Chem, Seoul 151747, South Korea

[2] Seoul Natl Univ, Dept Biophys & Chem Biol, BioMAX Inst, Seoul 151747, South Korea

[3] Soongsil Univ, Dept Chem, Seoul 156743, South Korea

来源：

SUPRAMOLECULAR CHEMISTRY | 2013年 / 25卷 / 01期

关键词：

fluorescent sensor; zinc ion; PeT; cell imaging; MOBILE ZINC; SENSOR; RECOGNITION; APOPTOSIS; SWITCHES; HEALTH; CELLS;

D O I：

10.1080/10610278.2012.720020

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A synthetic fluorescent sensor (sensor 1) is developed using boron-dipyrromethene as a fluorophore and phenoxo-bridged dipicolylamine as a receptor. Sensor 1 shows a significant enhancement of fluorescent intensity and a high selectivity for Zn2+ over various metal cations. The electrochemical study provides a rationale for the fluorescence turn-on of sensor 1 upon complexation with Zn2+ by the blocking of the photo-induced electron transfer mechanism. Sensor 1 can be used to image Zn2+ in A549 cells.

引用

页码：2 / 6

页数：5

共 26 条

[1] Understanding Zinc Quantification with Existing and Advanced Ditopic Fluorescent Zinpyr Sensors [J].

Buccella, Daniela ;

Horowitz, Joshua A. ;

Lippard, Stephen J. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (11) :4101-4114

[2] Meeting of the minds: Metalloneurochemistry [J].

Burdette, SC ;

Lippard, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3605-3610

[3] Luminescent sensors and switches in the early 21st century [J].

Callan, JF ;

de Silva, AP ;

Magri, DC .

TETRAHEDRON, 2005, 61 (36) :8551-8588

[4] Ratiometric and near-infrared molecular probes for the detection and imaging of zinc ions [J].

Carol, Priya ;

Sreejith, Sivaramapanicker ;

Ajayaghosh, Ayyappanpillai .

CHEMISTRY-AN ASIAN JOURNAL, 2007, 2 (03) :338-348

[5]

de Silva A.P., 1986, CHEM COMMUN, P1709

[6] Signaling recognition events with fluorescent sensors and switches [J].

de Silva, AP ;

Gunaratne, HQN ;

Gunnlaugsson, T ;

Huxley, AJM ;

McCoy, CP ;

Rademacher, JT ;

Rice, TE .

CHEMICAL REVIEWS, 1997, 97 (05) :1515-1566

[7] A Highly Selective Turn-On Colorimetric, Red Fluorescent Sensor for Detecting Mobile Zinc in Living Cells [J].

Du, Pingwu ;

Lippard, Stephen J. .

INORGANIC CHEMISTRY, 2010, 49 (23) :10753-10755

[8] The neurobiology of zinc in health and disease [J].

Frederickson, CJ ;

Koh, JY ;

Bush, AI .

NATURE REVIEWS NEUROSCIENCE, 2005, 6 (06) :449-462

[9] Zinc and health: Current status and future directions - Introduction [J].

Hambidge, M ;

Cousins, RJ ;

Costello, RB .

JOURNAL OF NUTRITION, 2000, 130 (05) :1341S-1343S

[10] ILLUMINATING MOBILE ZINC WITH FLUORESCENCE: FROM CUVETTES TO LIVE CELLS AND TISSUES [J].

Huang, Zhen ;

Lippard, Stephen J. .

METHODS IN ENZYMOLOGY, VOL 505: IMAGING AND SPECTROSCOPIC ANALYSIS OF LIVING CELLS: LIVE CELL IMAGING OF CELLULAR ELEMENTS AND FUNCTIONS, 2012, 505 :445-468

← 1 2 3 →