let-7 microRNAs in development, stem cells and cancer

被引：512

作者：

Buessing, Ingo ^{[1
]}

Slack, Frank J. ^{[2
]}

Grosshans, Helge ^{[1
]}

机构：

[1] Novartis Res Fdn, Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland

[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2008年 / 14卷 / 09期

基金：

美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

D O I：

10.1016/j.molmed.2008.07.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are small noncoding RNAs, similar to 22 nucleotides in length, that repress target messenger RNAs (mRNAs) through an antisense mechanism. The let-7 miRNA was originally discovered in the nematode Caenorhabditis elegans, where it regulates cell proliferation and differentiation, but subsequent work has shown that both its sequence and its function are highly conserved in mammals. Recent results have now linked decreased let-7 expression to increased tumorigenicity and poor patient prognosis. Moreover, during normal development, accumulation of let-7 can be prevented by LIN28, a promoter of pluripotency. Based on these findings, we propose that let-7 regulates 'stemness' by repressing self-renewal and promoting differentiation in both normal development and cancer. A more complete understanding of its function will thus provide insights into these processes and might yield diagnostic and therapeutic advances for cancer treatment.

引用

页码：400 / 409

页数：10

共 97 条

[1] The let-7 microRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans [J].

Abbott, AL ;

Alvarez-Saavedra, E ;

Miska, EA ;

Lau, NC ;

Bartel, DP ;

Horvitz, HR ;

Ambros, V .

DEVELOPMENTAL CELL, 2005, 9 (03) :403-414

[2] The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs [J].

Abrahante, JE ;

Daul, AL ;

Li, M ;

Volk, ML ;

Tennessen, JM ;

Miller, EA ;

Rougvie, AE .

DEVELOPMENTAL CELL, 2003, 4 (05) :625-637

[3]

Ahrendt SA, 2001, CANCER, V92, P1525, DOI 10.1002/1097-0142(20010915)92:6<1525::AID-CNCR1478>3.0.CO

[4]

2-H

[5] Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules [J].

Balzer, Erica ;

Moss, Eric G. .

RNA BIOLOGY, 2007, 4 (01) :16-25

[6] Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression [J].

Banerjee, D ;

Slack, F .

BIOESSAYS, 2002, 24 (02) :119-129

[7] Identification of let-7-regulated oncofetal genes [J].

Boyerinas, Benjamin ;

Park, Sun-Mi ;

Shomron, Noam ;

Hedegaard, Mads M. ;

Vinther, Jeppe ;

Andersen, Jens S. ;

Feig, Christine ;

Xu, Jinbo ;

Burg, Christopher B. ;

Peter, Marcus E. .

CANCER RESEARCH, 2008, 68 (08) :2587-2591

[8] The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function [J].

Brueckner, Bodo ;

Stresemann, Carlo ;

Kuner, Ruprecht ;

Mund, Cora ;

Musch, Tanja ;

Meister, Michael ;

Sueltmann, Holger ;

Lyko, Frank .

CANCER RESEARCH, 2007, 67 (04) :1419-1423

[9] MicroRNA functions [J].

Bushati, Natascha ;

Cohen, Stephen M. .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2007, 23 :175-205

[10] Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers [J].

Calin, GA ;

Sevignani, C ;

Dan Dumitru, C ;

Hyslop, T ;

Noch, E ;

Yendamuri, S ;

Shimizu, M ;

Rattan, S ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :2999-3004

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