Prediction of Advanced Fibrosis in Nonalcoholic Fatty Liver Disease: An Enhanced Model of BARD Score

被引:27
|
作者
Lee, Tae Hoon [1 ]
Han, Seung Hye [2 ]
Yang, Ju Dong [3 ]
Kim, Donghee [3 ,4 ]
Ahmed, Monjur [5 ]
机构
[1] Marshall Univ, Sch Med, Dept Internal Med, Huntington, WV USA
[2] NIH, Bethesda, MD 20892 USA
[3] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA
[4] Seoul Natl Univ Hosp Healthcare Syst, Inst Healthcare Res, Dept Internal Med, Seoul, South Korea
[5] Thomas Jefferson Univ, Jefferson Med Coll, Div Gastroenterol & Hepatol, Philadelphia, PA 19107 USA
关键词
Non-alcoholic fatty liver disease; Liver cirrhosis; International normalized ratio; HEPATIC STEATOSIS; UNITED-STATES; NAFLD; PREVALENCE; STEATOHEPATITIS; POPULATION; DIAGNOSIS; STIFFNESS; MARKERS; SYSTEM;
D O I
10.5009/gnl.2013.7.3.323
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims: The BARD score is a model to detect advanced liver fibrosis in nonalcoholic fatty liver disease (NAFLD) patients. The aims of this study were to identify additional factors and then to build an enhanced version of the BARD score. Methods: One hundred seven patients with biopsy-proven NAFLD were enrolled retrospectively. Logistic regressions were performed to identify independent risk factors for advanced liver fibrosis (stage 3 or 4). An enhanced model of the BARD score (BARDI score) was built and evaluated with a receiver operating characteristic (ROC) curve. Results: In multivariate analysis, age (odds ratio [OR], 0.89; p=0.04), aspartate aminotransferase/alanine aminotransferase ratio (OR, 1.73; p<0.01), and international normalized ratio (INR) (OR, 8.85; p<0.01) were independently significant factors. The BARDI score was created by adding the INR to the BARD. The area under the ROC curve of the BARDI score was significantly larger than that of the BARD score (0.881 vs 0.808, p<0.01). A BARDI score of 3 or more showed a positive predictive value (PPV) of 51.0% and a negative predictive value (NPV) of 96.0%. Conclusions: The BARDI score had an improved PPV over the BARD score and maintained an excellent NPV. Further study is warranted for its external validation and comparison with other models.
引用
收藏
页码:323 / 328
页数:6
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