Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk

被引：183

作者：

Brand, Judith S. ^{[1
]}

van der Schouw, Yvonne T. ^{[1
]}

Onland-Moret, N. Charlotte ^{[1
]}

Sharp, Stephen J. ^{[2
]}

Ong, Ken K. ^{[2
]}

Khaw, Kay-Tee ^{[3
]}

Ardanaz, Eva ^{[4
,5
]}

Amiano, Pilar ^{[5
,6
,7
]}

Boeing, Heiner ^{[8
]}

Chirlaque, Maria-Dolores ^{[5
,9
]}

Clavel-Chapelon, Francoise ^{[10
]}

Crowe, Francesca L. ^{[11
]}

de Lauzon-Guillain, Blandine ^{[10
,12
]}

Duell, Eric J. ^{[13
]}

Fagherazzi, Guy ^{[10
,12
]}

Franks, Paul W. ^{[14
,15
]}

Grioni, Sara ^{[16
]}

Groop, Leif C. ^{[17
,18
]}

Kaaks, Rudolf ^{[19
]}

Key, Timothy J. ^{[11
]}

Nilsson, Peter M. ^{[20
]}

Overvad, Kim ^{[21
,22
]}

Palli, Domenico ^{[23
]}

Panico, Salvatore ^{[24
]}

Quiros, J. Ramon ^{[25
]}

Rolandsson, Olov ^{[26
]}

Sacerdote, Carlotta ^{[27
,28
]}

Sanchez, Maria-Jose ^{[5
,29
]}

Slimani, Nadia ^{[30
]}

Teucher, Birgit ^{[19
]}

Tjonneland, Anne ^{[31
]}

Tumino, Rosario ^{[32
,33
]}

van der A, Daphne L. ^{[34
]}

Feskens, Edith J. M. ^{[35
]}

Langenberg, Claudia

Forouhi, Nita G. ^{[2
]}

Riboli, Elio ^{[36
]}

Wareham, Nicholas J. ^{[2
]}

机构：

[1] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[2] Addenbrookes Hosp, Med Res Council Epidemiol Unit, Inst Metab Sci, Cambridge, England

[3] Univ Cambridge, Addenbrookes Hosp, Dept Publ Hlth & Primary Care, Cambridge CB2 2QQ, England

[4] Navarre Publ Hlth Inst, Pamplona, Spain

[5] Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain

[6] Basque Govt, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[7] Basque Govt, Inst BIOdonostia, San Sebastian, Spain

[8] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[9] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[10] Inst Gustave Roussy, INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Nutr Hormones & Womens Hlth U1018, F-94805 Villejuif, France

[11] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[12] Univ Paris 11, UMRS 1018, Villejuif, France

[13] Canc Epidemiol Res Program, Unit Nutr Environm & Canc, Barcelona, Spain

[14] Lund Univ, Malmo Gen Hosp, Dept Clin Sci, Clin Res Ctr, S-21401 Malmo, Sweden

[15] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[16] Fdn IRCCS Ist Nazl Tumori Milano, Milan, Italy

[17] Lund Univ, Dept Clin Sci Diabet & Endocrinol, Univ Hosp Scania, Malmo, Sweden

[18] Univ Helsinki, Insitute Mol Med Finland FIMM, Helsinki, Finland

[19] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[20] Lund Univ, Dept Clin Sci, Univ Hosp Scania, Malmo, Sweden

[21] Aarhus Univ, Dept Epidemiol, Sch Publ Hlth, Aarhus, Denmark

[22] Aarhus Univ Hosp, Aalborg Hosp, Dept Cardiol, Aalborg, Denmark

[23] Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy

[24] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[25] Publ Hlth Directorate, Oviedo, Spain

[26] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[27] Ctr Canc Prevent CPO Piemonte, Turin, Italy

[28] Human Genet Fdn, Turin, Italy

[29] Andalusian Sch Publ Hlth, Granada, Spain

[30] Int Agcy Res Canc, Dietary Exposure Assessment Grp, Lyon, France

[31] Danish Canc Soc Res Ctr, Strandboulevarden Copenh, Denmark

[32] Civile MP Arezzo Hosp, Canc Registry & Histopathol Unit, Ragusa, Italy

[33] Assoc Iblea Ric Epidemiol Onlus, Ragusa, Italy

[34] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[35] Wageningen Univ, Sect Nutr & Epidemiol, Div Human Nutr, NL-6700 AP Wageningen, Netherlands

[36] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England

来源：

DIABETES CARE | 2013年 / 36卷 / 04期

基金：

英国医学研究理事会; 瑞典研究理事会;

关键词：

BODY-SIZE; BREAST-CANCER; WOMEN; DISEASE; REPRODUCIBILITY; ENDOMETRIAL; ESTROGENS; VALIDITY; MENARCHE; HORMONES;

D O I：

10.2337/dc12-1020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE-Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. RESEARCH DESIGN AND METHODS-Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied. RESULTS-Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86-1.10), and 0.85 (0.70-1.03) for women with menopause at ages <40, 40-44, 45-49, and >= 55 years, respectively, relative to those with menopause at age 50-54 years. The HR per SD younger age at menopause was 1.08 (1.02-1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [ 1.01-1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05). CONCLUSIONS-Early menopause is associated with a greater risk of type 2 diabetes. Diabetes Care 36:1012-1019, 2013

引用

页码：1012 / 1019

页数：8

共 40 条

[21] Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
Langenberg, C.
Sharp, S.
Forouhi, N. G.
Franks, P. W.
Schulze, M. B.
Kerrison, N.
Ekelund, U.
Barroso, I.
Panico, S.
Tormo, M. J.
Spranger, J.
Griffin, S.
van der Schouw, Y. T.
Amiano, P.
Ardanaz, E.
Arriola, L.
Balkau, B.
Barricarte, A.
Beulens, J. W. J.
Boeing, H.
Bueno-de-Mesquita, H. B.
Buijsse, B.
Chirlaque Lopez, M. D.
Clavel-Chapelon, F.
Crowe, F. L.
de Lauzon-Guillan, B.
Deloukas, P.
Dorronsoro, M.
Drogan, D.
Froguel, P.
Gonzalez, C.
Grioni, S.
Groop, L.
Groves, C.
Hainaut, P.
Halkjaer, J.
Hallmans, G.
Hansen, T.
Huerta Castano, J. M.
Kaaks, R.
Key, T. J.
Khaw, K. T.
Koulman, A.
Mattiello, A.
Navarro, C.
Nilsson, P.
Norat, T.
Overvad, K.
Palla, L.
Palli, D.
[J]. DIABETOLOGIA, 2011, 54 (09) : 2272 - 2282
[22] Premature menopause in a multi-ethnic population study of the menopause transition
Luborsky, JL
Meyer, P
Sowers, MF
Gold, EB
Santoro, N
[J]. HUMAN REPRODUCTION, 2003, 18 (01) : 199 - 206
[23] Menopause in normal and uncomplicated NIDDM women: physical and emotional symptoms and hormone profile
Malacara, JM
Huerta, R
Rivera, B
Esparza, S
Fajardo, ME
[J]. MATURITAS, 1997, 28 (01) : 35 - 45
[24] Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: results from the Women's Health Initiative Hormone Trial
Margolis, KL
Bonds, DE
Rodabough, RJ
Tinker, L
Phillips, LS
Allen, C
Bassford, T
Burke, G
Torrens, J
Howard, BV
[J]. DIABETOLOGIA, 2004, 47 (07) : 1175 - 1187
[25] Short-term weight change and the incidence of diabetes in midlife - Results from the Australian Longitudinal Study on Women's Health
Mishra, Gita D.
Carrigan, Gretchen
Brown, Wendy J.
Barnett, Adrian G.
Dobson, Annette J.
[J]. DIABETES CARE, 2007, 30 (06) : 1418 - 1424
[26] Early age at menopause and breast cancer: are leaner women more protected? A prospective analysis of the Dutch DOM cohort
Monninkhof, EM
van der Schouw, YT
Peeters, PHM
[J]. BREAST CANCER RESEARCH AND TREATMENT, 1999, 55 (03) : 285 - 291
[27] Recall of early menstrual history and menarcheal body size: After 30 years, how well do women remember?
Must, A
Phillips, SM
Naumova, EN
Blum, M
Harris, S
Dawson-Hughes, B
Rand, WM
[J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2002, 155 (07) : 672 - 679
[28] Risk factors for type 2 diabetes in women attending menopause clinics in Italy: a cross-sectional study
Parazzini, F
[J]. CLIMACTERIC, 2005, 8 (03) : 287 - 293
[29] Estrogens in the causation of breast, endometrial and ovarian cancers - evidence and hypotheses from epidemiological findings
Persson, I
[J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2000, 74 (05) : 357 - 364
[30] Glucose tolerance of premenopausal women after menopause due to surgical removal of ovaries
Pirimoglu, Z. M.
Arslan, C.
Buyukbayrak, E. E.
Kars, B.
Karsidag, Y. K.
Unal, O.
Turan, M. C.
[J]. CLIMACTERIC, 2011, 14 (04) : 453 - 457

← 1 2 3 4 →