Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk

被引：192

作者：

Brand, Judith S. ^{[1
]}

van der Schouw, Yvonne T. ^{[1
]}

Onland-Moret, N. Charlotte ^{[1
]}

Sharp, Stephen J. ^{[2
]}

Ong, Ken K. ^{[2
]}

Khaw, Kay-Tee ^{[3
]}

Ardanaz, Eva ^{[4
,5
]}

Amiano, Pilar ^{[5
,6
,7
]}

Boeing, Heiner ^{[8
]}

Chirlaque, Maria-Dolores ^{[5
,9
]}

Clavel-Chapelon, Francoise ^{[10
]}

Crowe, Francesca L. ^{[11
]}

de Lauzon-Guillain, Blandine ^{[10
,12
]}

Duell, Eric J. ^{[13
]}

Fagherazzi, Guy ^{[10
,12
]}

Franks, Paul W. ^{[14
,15
]}

Grioni, Sara ^{[16
]}

Groop, Leif C. ^{[17
,18
]}

Kaaks, Rudolf ^{[19
]}

Key, Timothy J. ^{[11
]}

Nilsson, Peter M. ^{[20
]}

Overvad, Kim ^{[21
,22
]}

Palli, Domenico ^{[23
]}

Panico, Salvatore ^{[24
]}

Quiros, J. Ramon ^{[25
]}

Rolandsson, Olov ^{[26
]}

Sacerdote, Carlotta ^{[27
,28
]}

Sanchez, Maria-Jose ^{[5
,29
]}

Slimani, Nadia ^{[30
]}

Teucher, Birgit ^{[19
]}

Tjonneland, Anne ^{[31
]}

Tumino, Rosario ^{[32
,33
]}

van der A, Daphne L. ^{[34
]}

Feskens, Edith J. M. ^{[35
]}

Langenberg, Claudia

Forouhi, Nita G. ^{[2
]}

Riboli, Elio ^{[36
]}

Wareham, Nicholas J. ^{[2
]}

机构：

[1] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[2] Addenbrookes Hosp, Med Res Council Epidemiol Unit, Inst Metab Sci, Cambridge, England

[3] Univ Cambridge, Addenbrookes Hosp, Dept Publ Hlth & Primary Care, Cambridge CB2 2QQ, England

[4] Navarre Publ Hlth Inst, Pamplona, Spain

[5] Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain

[6] Basque Govt, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[7] Basque Govt, Inst BIOdonostia, San Sebastian, Spain

[8] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[9] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[10] Inst Gustave Roussy, INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Nutr Hormones & Womens Hlth U1018, F-94805 Villejuif, France

[11] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[12] Univ Paris 11, UMRS 1018, Villejuif, France

[13] Canc Epidemiol Res Program, Unit Nutr Environm & Canc, Barcelona, Spain

[14] Lund Univ, Malmo Gen Hosp, Dept Clin Sci, Clin Res Ctr, S-21401 Malmo, Sweden

[15] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[16] Fdn IRCCS Ist Nazl Tumori Milano, Milan, Italy

[17] Lund Univ, Dept Clin Sci Diabet & Endocrinol, Univ Hosp Scania, Malmo, Sweden

[18] Univ Helsinki, Insitute Mol Med Finland FIMM, Helsinki, Finland

[19] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[20] Lund Univ, Dept Clin Sci, Univ Hosp Scania, Malmo, Sweden

[21] Aarhus Univ, Dept Epidemiol, Sch Publ Hlth, Aarhus, Denmark

[22] Aarhus Univ Hosp, Aalborg Hosp, Dept Cardiol, Aalborg, Denmark

[23] Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy

[24] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[25] Publ Hlth Directorate, Oviedo, Spain

[26] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[27] Ctr Canc Prevent CPO Piemonte, Turin, Italy

[28] Human Genet Fdn, Turin, Italy

[29] Andalusian Sch Publ Hlth, Granada, Spain

[30] Int Agcy Res Canc, Dietary Exposure Assessment Grp, Lyon, France

[31] Danish Canc Soc Res Ctr, Strandboulevarden Copenh, Denmark

[32] Civile MP Arezzo Hosp, Canc Registry & Histopathol Unit, Ragusa, Italy

[33] Assoc Iblea Ric Epidemiol Onlus, Ragusa, Italy

[34] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[35] Wageningen Univ, Sect Nutr & Epidemiol, Div Human Nutr, NL-6700 AP Wageningen, Netherlands

[36] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England

来源：

DIABETES CARE | 2013年 / 36卷 / 04期

基金：

英国医学研究理事会; 瑞典研究理事会;

关键词：

BODY-SIZE; BREAST-CANCER; WOMEN; DISEASE; REPRODUCIBILITY; ENDOMETRIAL; ESTROGENS; VALIDITY; MENARCHE; HORMONES;

D O I：

10.2337/dc12-1020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE-Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. RESEARCH DESIGN AND METHODS-Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied. RESULTS-Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86-1.10), and 0.85 (0.70-1.03) for women with menopause at ages <40, 40-44, 45-49, and >= 55 years, respectively, relative to those with menopause at age 50-54 years. The HR per SD younger age at menopause was 1.08 (1.02-1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [ 1.01-1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05). CONCLUSIONS-Early menopause is associated with a greater risk of type 2 diabetes. Diabetes Care 36:1012-1019, 2013

引用

页码：1012 / 1019

页数：8

共 40 条

[21] Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study [J].

Langenberg, C. ;

Sharp, S. ;

Forouhi, N. G. ;

Franks, P. W. ;

Schulze, M. B. ;

Kerrison, N. ;

Ekelund, U. ;

Barroso, I. ;

Panico, S. ;

Tormo, M. J. ;

Spranger, J. ;

Griffin, S. ;

van der Schouw, Y. T. ;

Amiano, P. ;

Ardanaz, E. ;

Arriola, L. ;

Balkau, B. ;

Barricarte, A. ;

Beulens, J. W. J. ;

Boeing, H. ;

Bueno-de-Mesquita, H. B. ;

Buijsse, B. ;

Chirlaque Lopez, M. D. ;

Clavel-Chapelon, F. ;

Crowe, F. L. ;

de Lauzon-Guillan, B. ;

Deloukas, P. ;

Dorronsoro, M. ;

Drogan, D. ;

Froguel, P. ;

Gonzalez, C. ;

Grioni, S. ;

Groop, L. ;

Groves, C. ;

Hainaut, P. ;

Halkjaer, J. ;

Hallmans, G. ;

Hansen, T. ;

Huerta Castano, J. M. ;

Kaaks, R. ;

Key, T. J. ;

Khaw, K. T. ;

Koulman, A. ;

Mattiello, A. ;

Navarro, C. ;

Nilsson, P. ;

Norat, T. ;

Overvad, K. ;

Palla, L. ;

Palli, D. .

DIABETOLOGIA, 2011, 54 (09) :2272-2282

[22] Premature menopause in a multi-ethnic population study of the menopause transition [J].

Luborsky, JL ;

Meyer, P ;

Sowers, MF ;

Gold, EB ;

Santoro, N .

HUMAN REPRODUCTION, 2003, 18 (01) :199-206

[23] Menopause in normal and uncomplicated NIDDM women: physical and emotional symptoms and hormone profile [J].

Malacara, JM ;

Huerta, R ;

Rivera, B ;

Esparza, S ;

Fajardo, ME .

MATURITAS, 1997, 28 (01) :35-45

[24] Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: results from the Women's Health Initiative Hormone Trial [J].

Margolis, KL ;

Bonds, DE ;

Rodabough, RJ ;

Tinker, L ;

Phillips, LS ;

Allen, C ;

Bassford, T ;

Burke, G ;

Torrens, J ;

Howard, BV .

DIABETOLOGIA, 2004, 47 (07) :1175-1187

[25] Short-term weight change and the incidence of diabetes in midlife - Results from the Australian Longitudinal Study on Women's Health [J].

Mishra, Gita D. ;

Carrigan, Gretchen ;

Brown, Wendy J. ;

Barnett, Adrian G. ;

Dobson, Annette J. .

DIABETES CARE, 2007, 30 (06) :1418-1424

[26] Early age at menopause and breast cancer: are leaner women more protected? A prospective analysis of the Dutch DOM cohort [J].

Monninkhof, EM ;

van der Schouw, YT ;

Peeters, PHM .

BREAST CANCER RESEARCH AND TREATMENT, 1999, 55 (03) :285-291

[27] Recall of early menstrual history and menarcheal body size: After 30 years, how well do women remember? [J].

Must, A ;

Phillips, SM ;

Naumova, EN ;

Blum, M ;

Harris, S ;

Dawson-Hughes, B ;

Rand, WM .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2002, 155 (07) :672-679

[28] Risk factors for type 2 diabetes in women attending menopause clinics in Italy: a cross-sectional study [J].

Parazzini, F .

CLIMACTERIC, 2005, 8 (03) :287-293

[29] Estrogens in the causation of breast, endometrial and ovarian cancers - evidence and hypotheses from epidemiological findings [J].

Persson, I .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2000, 74 (05) :357-364

[30] Glucose tolerance of premenopausal women after menopause due to surgical removal of ovaries [J].

Pirimoglu, Z. M. ;

Arslan, C. ;

Buyukbayrak, E. E. ;

Kars, B. ;

Karsidag, Y. K. ;

Unal, O. ;

Turan, M. C. .

CLIMACTERIC, 2011, 14 (04) :453-457

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