Copper-Mediated Oxidative Functionalization of C(sp3)-H Bonds with Isoquinolines: Two-Step Synthesis of 5-Oxaprotoberberinones

被引：2
|
作者：
Wang, Dingyi [1 ]
Zhang, Rongxing [1 ]
Deng, Ruihong [1 ]
Lin, Sen [1 ]
Guo, Shengmei [1 ]
Yan, Zhaohua [1 ]
机构：
[1] Nanchang Univ, Coll Chem, Nanchang 330031, Jiangxi, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 22期
基金：
中国国家自然科学基金;
关键词：
C-H AMINATION; EFFICIENT SYNTHESIS; METAL-FREE; AMIDATION; HYDROCARBONS; CYCLIZATION; ROSETTACIN; ACTIVATION; ANNULATION; ALKALOIDS;
D O I：
10.1021/acs.joc.6b02145
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-mediated oxidative functionalization of C(sp(3))-H bonds with isoquinolines via a radical process without ligands was achieved. The present system exhibits a novel pathway for the preparation of N-alkyl (benzyl) isoquinolin-1(2H)-ones in moderate to high yields. In addition, this procedure provides a simple method to afford 5-oxaprotoberberinones and their derivatives in two steps.
引用
收藏
页码：11162 / 11167
页数：6
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