Retinol palmitate protects against myocardial ischemia/reperfusion injury via reducing oxidative stress and inhibiting apoptosis

被引：2
|
作者：
Tao, Luyuan [1 ,3 ]
Huang, Kaiyu [1 ]
Wang, Jiaoni [1 ]
Xue, Yangjing [1 ]
Zhou, Yingying [1 ]
He, Fei [1 ]
Shen, Yigen [1 ]
Wang, Jinsheng [1 ]
Gu, Xingjian [3 ]
Ji, Kangting [1 ]
Qian, Lu [1 ]
Guo, Xianyang [2 ]
机构：
[1] Wenzhou Med Univ, Dept Cardiol, Affiliated & Yuying Childrens Hosp 2, Xueyuanxi Rd 109, Wenzhou 325000, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Intens Care Unit, Affiliated & Yuying Childrens Hosp 2, Xueyuanxi Rd 109, Wenzhou 325000, Zhejiang, Peoples R China
[3] Wenzhou Med Univ, Dept Cardiol, Huangyan Hosp, Hengjie Rd 218, Taizhou 318020, Zhejiang, Peoples R China
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2019年 / 11卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Retinol palmitate; antioxidant; apoptosis; myocardial ischemia reperfusion injury; VITAMIN-A; SUPEROXIDE-DISMUTASE; ANTIOXIDANT ACTIVITY; REPERFUSION INJURY; CELLULAR DEFENSES; FREE-RADICALS; RAT HEARTS; ISCHEMIA; INFARCTION; DAMAGE;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The purpose of this study was to determine whether retinol palmitate could protect against myocardial ischemia/reperfusion (I/R) injury and explore the underlying mechanism. Retinol palmitate reduced the level of reactive oxygen species and prevented cellular apoptosis. In vivo, retinol palmitate increased superoxide dismutase (SOD) activity and reduced the level of malondialdehyde in I/R mice. Retinol palmitate also decreased myocardial infarct size and reduced cellular apoptosis by suppressing the expression of proapoptotic-related proteins and increasing that of SOD-related proteins. Our results suggest that retinol palmitate pretreatment has a protective effect against myocardial I/R injury by maintaining the balance between intracellular oxidants and antioxidants.
引用
收藏
页码：1510 / 1520
页数：11
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