Co-administration of adjuvants along with Moringa oleifera attenuates beryllium-induced oxidative stress and histopathological alterations in rats

被引:24
|
作者
Das Agrawal, Narottam [1 ]
Nirala, Satendra Kumar [2 ]
Shukla, Sangeeta [1 ]
Mathur, Ramesh [1 ]
机构
[1] Jiwaji Univ, Dept Zool, Reprod Biol & Toxicol Lab, Gwalior 474011, Madhya Pradesh, India
[2] Guru Ghasidas Vishwavidyalaya, Dept Rural Technol & Social Dev, Bilaspur, Chhattisgarh, India
关键词
Beryllium toxicity; comet assay; curcumin; histopathology; piperine; GENE-EXPRESSION; ANTIOXIDANT; PIPERINE; ACID; TOXICITY; PROTECTS; CURCUMIN; TIFERRON; ENZYMES; ASSAY;
D O I
10.3109/13880209.2014.986685
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Context: Moringa oleifera Lam. (Moringaceae) is a rich source of antioxidants. All parts of the plant are medicinally important and have been used as traditional medicine for a variety of human ailments in India. Objective: Therapeutic efficacy of adjuvants with M. oleifera (MO) root extract was investigated against beryllium-induced oxidative stress. Materials and methods: Hydroalcoholic (50% v/v) root extract of M. oleifera (150 mg/kg, p.o.) alone and combinations of M. oleifera with either piperine (2.5 mg/kg, p.o.) or curcumin (5.0 mg/kg, p.o.) daily for 1 week were administered in experimental rats against beryllium toxicity (1.0 mg/kg, i.p. daily for 5 weeks). Oxidative stress parameters including blood sugar, G-6-Pase in liver, and DNA damage were analyzed. Histopathological changes in liver and kidney were also observed. Results: Beryllium enhanced lipid peroxidation (LPO), depleted reduced glutathione (GSH) and antioxidant enzymes activities, decreased blood sugar and G-6-Pase activity, and did not damage DNA. Histologically, liver was observed with structural loss and disintegration of hepatocytes, heavy vacuolation in hepatocytes, and kidney was observed with constriction of glomeruli and hypertrophy in epithelial cells of uriniferous tubules. Therapy of M. oleifera with piperine was effective; however, combination of M. oleifera with curcumin showed better therapeutic effect by reduction of LPO, elevated GSH level, maintained antioxidant enzymes activities, restored blood sugar, and G-6-Pase activity in liver together with almost normal histoarchitecture of liver and kidney. Discussion and conclusion: Curcumin enhanced therapeutic efficacy of M. oleifera root extract and showed better antioxidant potential against beryllium toxicity.
引用
收藏
页码:1465 / 1473
页数:9
相关论文
共 50 条
  • [31] Co-administration of iron sulphate and nitroglycerin promoted oxidative stress and mild tissue damage in Wistar rats
    Adeyemi O.S.
    Sulaiman F.A.
    Comparative Clinical Pathology, 2014, 23 (5) : 1525 - 1533
  • [32] Protective Effects of Co-administration of Zinc and Selenium Against Streptozotocin-Induced Alzheimer's Disease: Behavioral, Mitochondrial Oxidative Stress, and GPR39 Expression Alterations in Rats
    Farbood, Yaghoob
    Sarkaki, Alireza
    Mahdavinia, Masoud
    Ghadiri, Ata
    Teimoori, Ali
    Seif, Faezeh
    Dehghani, Mohammad Amin
    Navabi, Seyedeh Parisa
    NEUROTOXICITY RESEARCH, 2020, 38 (02) : 398 - 407
  • [33] Protective Effects of Co-administration of Zinc and Selenium Against Streptozotocin-Induced Alzheimer’s Disease: Behavioral, Mitochondrial Oxidative Stress, and GPR39 Expression Alterations in Rats
    Yaghoob Farbood
    Alireza Sarkaki
    Masoud Mahdavinia
    Ata Ghadiri
    Ali Teimoori
    Faezeh Seif
    Mohammad Amin Dehghani
    Seyedeh Parisa Navabi
    Neurotoxicity Research, 2020, 38 : 398 - 407
  • [34] Targeting oxidative stress attenuates malonic acid induced Huntington like behavioral and mitochondrial alterations in rats
    Kalonia, Harikesh
    Kumar, Puneet
    Kumar, Anil
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2010, 634 (1-3) : 46 - 52
  • [35] Graviola (Annona muricata) attenuates behavioural alterations and testicular oxidative stress induced by streptozotocin in diabetic rats
    Alsenosy, Abdel-wahab A.
    El-Far, Ali H.
    Sadek, Kadry M.
    Ibrahim, Safinaz A.
    Atta, Mustafa S.
    Sayed-Ahmed, Ahmed
    Al Jaouni, Soad K.
    Mousa, Shaker A.
    PLOS ONE, 2019, 14 (09):
  • [36] Targeting oxidative stress attenuates malonic acid induced Huntington like behavioral and mitochondrial alterations in rats
    Kalonia, H.
    Kumar, A.
    MOVEMENT DISORDERS, 2011, 26 : S62 - S62
  • [37] Protective effects of vitamins (C and E) and melatonin co-administration on hematological and hepatic functions and oxidative stress in alloxan-induced diabetic rats
    Allagui, Mohamed Salah
    Feriani, Anouer
    Bouoni, Zouhour
    Alimi, Hichem
    Murat, Jean Claud
    El Feki, Abdelfattah
    JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2014, 70 (03) : 713 - 723
  • [38] Effect of fatty acids from ethanol extract of Moringa oleifera seeds on kidney function impairment and oxidative stress induced by gentamicin in rats
    Nafiu, Aliyat O.
    Akomolafe, Rufus O.
    Alabi, Quadri K.
    Idowu, Clement O.
    Odujoko, Oluwole O.
    BIOMEDICINE & PHARMACOTHERAPY, 2019, 117
  • [39] Protective effects of vitamins (C and E) and melatonin co-administration on hematological and hepatic functions and oxidative stress in alloxan-induced diabetic rats
    Mohamed Salah Allagui
    Anouer Feriani
    Zouhour Bouoni
    Hichem Alimi
    Jean Claud Murat
    Abdelfattah El Feki
    Journal of Physiology and Biochemistry, 2014, 70 : 713 - 723
  • [40] Lead induced oxidative stress and its recovery following co-administration of melatonin or N-acetylcysteine during chelation with succimer in male rats
    Flora, SJS
    Pande, M
    Kannan, GM
    Mehta, A
    CELLULAR AND MOLECULAR BIOLOGY, 2004, 50 : 543 - 551