Palladium-catalyzed cascade reactions of 3-iodochromones with aryl iodides and norbornadiene leading to annulated xanthones

被引：46

作者：

Cheng, Ming ^{[1
]}

Yan, Jianwei ^{[1
]}

Hu, Feng ^{[1
]}

Chen, Hong ^{[1
]}

Hu, Youhong ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

CHEMICAL SCIENCE | 2013年 / 4卷 / 01期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; TANDEM REACTION; 1,3-DICARBONYL COMPOUNDS; EFFICIENT APPROACH; DIRECT ARYLATION; O-TERARYLS; NORBORNENE; DERIVATIVES; CHROMONES; FUNCTIONALIZATION;

D O I：

10.1039/c2sc21335d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient, palladium-catalyzed cascade reaction, which leads to formation of annulated xanthones, was devised. The process, which uses readily available 3-iodochromones, aryl iodides and norbornadiene as starting materials, takes place via a tandem Heck reaction/double C-H activation/retro-Diels-Alder pathway. The high chemoselectivity of the process is mechanistically unique and it serves as a new approach to achieve regioselective control of C-H activation in Pd/norbornene or norbornadiene systems. Its broad substrate scope, including heteroaryl coupling partners, enables access to diverse annulated xanthones.

引用

页码：526 / 530

页数：5

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