Monoterpenoid Indole Alkaloids from Alstonia yunnanensis and Their Cytotoxic and Anti-inflammatory Activities

被引：35

作者：

Cao, Peng ^{[1
]}

Liang, Yong ^{[1
]}

Gao, Xu ^{[1
]}

Li, Xiao-Ming ^{[1
]}

Song, Zhen-Quan ^{[1
]}

Liang, Guobiao ^{[1
]}

机构：

[1] Shenyang No Hosp, Shenyang Mil Area Command, Gen Hosp, Dept Neurosurg,Inst Neurol, Shenyang 110018, Peoples R China

来源：

MOLECULES | 2012年 / 17卷 / 11期

关键词：

Alstonia yunnanensis; Apocynaceae; monoterpenoid indole alkaloids; cytotoxicity; anti-inflammatory activities; A-D; SCHOLARIS; LEAVES; MACROPHYLLA; BISINDOLE; MACROLINE; ANGUSTIFOLIA; ACID;

D O I：

10.3390/molecules171113631

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 80% ethanol extract of Alstonia yunnanensis afforded five new monoterpenoid indole alkaloids: 11-hydroxy-6,7-epoxy-8-oxo-vincadifformine (1), 14-chloro-15-hydroxy-vincadifformine (2), perakine N-4-oxide (3), raucaffrinoline N-4-oxide (4), and vinorine N-1,N-4-dioxide (5), together with three known compounds: 11-methoxy-6,7-epoxy-8-oxo-vincadifformine (6), vinorine N-4-oxide (7) and vinorine (8). The structures of the isolated compounds were established based on 1D and 2D (H-1-H-1-COSY, HMQC, HMBC, and ROESY) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic potential against seven tumor cell lines and anti-inflammatory activities. Compounds 3, 4 and 7 exhibited weak cytotoxicity against the tested cell lines and selective inhibition of Cox-2 (>85%).

引用

页码：13631 / 13641

页数：11

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