Highly Modified Lanostane Triterpenes from the Wood-Rot Basidiomycete Ganoderma colossus: Comparative Chemical Investigations of Natural and Artificially Cultivated Fruiting Bodies and Mycelial Cultures

被引：13

作者：

Isaka, Masahiko ^{[1
]}

Chinthanom, Panida ^{[1
]}

Choeyklin, Rattaket ^{[1
]}

Thummarukcharoen, Tuksaporn ^{[2
]}

Rachtawee, Pranee ^{[1
]}

Sappan, Malipan ^{[1
]}

Srichomthong, Kitlada ^{[1
]}

Fujii, Ryoma ^{[3
]}

Kawashima, Kyohei ^{[3
]}

Mori, Seiji ^{[3
]}

机构：

[1] Natl Ctr Genet Engn & Biotechnol BIOTEC, Klongluang 12120, Pathumthani, Thailand

[2] Natl Biobank Thailand NBT, Klongluang 12120, Pathumthani, Thailand

[3] Ibaraki Univ, Inst Quantum Beam Sci, Mito, Ibaraki 3108512, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2020年 / 83卷 / 07期

关键词：

METABOLITES; LACTONES;

D O I：

10.1021/acs.jnatprod.9b00947

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The wood-rot basidiomycete Ganoderma colossus has been chemically investigated. Comparative analyses of the natural fruiting body, artificially cultivated fruiting bodies, and mycelial cultures resulted in the isolation, in total, of 13 new highly modified lanostanes, ganocolossusins A-H (1-8) and ganoder-malactones T-X (9-13), together with 23 known compounds (14-36). There were significant overlaps of the same compounds among the three different states of the fungal materials. Ganocolossusin D (4) displayed the most potent antimalarial activity against Plasmodium falciparum K1 (multi-drug-resistant strain) with an IC50 value of 2.4 mu M, while it was noncytotoxic to Vero cells at 50 mu g/mL.

引用

页码：2066 / 2075

页数：10

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