Neuroinflammatory pathways in anxiety, posttraumatic stress, and obsessive compulsive disorders

被引：125
作者：
Furtado, Melissa [1 ]
Katzman, Martin A. [1 ,2 ,3 ,4 ,5 ]
机构：
[1] START Clin Mood & Anxiety Disorders, Toronto, ON M4W 2N4, Canada
[2] Univ Toronto, Fac Med, Dept Psychiat, Toronto, ON M5S 1A1, Canada
[3] Northern Ontario Sch Med, Thunder Bay, ON, Canada
[4] Lakehead Univ, Dept Psychol, Thunder Bay, ON P7B 5E1, Canada
[5] Adler Grad Profess Sch, Toronto, ON, Canada
来源：
PSYCHIATRY RESEARCH | 2015年 / 229卷 / 1-2期
关键词：
Generalized anxiety disorder; Social anxiety disorder; Panic disorder; Posttraumatic stress disorder; Obsessive compulsive disorder; Inflammation; Hypothalamic pituitary adrenal axis; C-REACTIVE PROTEIN; PITUITARY-ADRENAL ACTIVITY; TUMOR-NECROSIS-FACTOR; GENERALIZED ANXIETY; SALIVARY CORTISOL; HAIR CORTISOL; TNF-ALPHA; HPA AXIS; DEPRESSIVE SYMPTOMS; PHYSICAL DISORDERS;
D O I：
10.1016/j.psychres.2015.05.036
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
As prevalence of anxiety, posttraumatic stress, and obsessive compulsive disorders continue to rise worldwide, increasing focus has been placed on immune mediated theories in understanding the underlying mechanisms of these disorders. Associations between the dysregulation of the hypothalamic pituitary adrenal (HPA) axis and these disorders have been recognized in the scientific literature, specifically in regard to cortisol levels, as well as changes in pro- and anti-inflammatory cytokines. The present commentary will systematically assess the scientific literature within the past decade in regard to the psychoneuroimmunology of anxiety, posttraumatic stress, and obsessive compulsive disorders. Understanding the mechanisms of these disorders is essential in order to determine efficacious and targeted treatment strategies, which may lead to substantial improvements in overall functioning, as well as significant decreases in societal and economic burden. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：37 / 48
页数：12
相关论文
共 89 条
[61]   Th2 cytokine response in Major Depressive Disorder patients before treatment [J].
Pavón, L ;
Sandoval-López, G ;
Hernández, ME ;
Loría, F ;
Estrada, I ;
Pérez, M ;
Moreno, J ;
Avila, U ;
Leff, P ;
Antón, B ;
Heinze, G .
JOURNAL OF NEUROIMMUNOLOGY, 2006, 172 (1-2) :156-165
[62]   Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorder and tic disorders in childhood [J].
Perlmutter, SJ ;
Leitman, SF ;
Garvey, MA ;
Hamburger, S ;
Feldman, E ;
Leonard, HL ;
Swedo, SE .
LANCET, 1999, 354 (9185) :1153-1158
[63]   A striking pattern of cortisol non-responsiveness to psychosocial stress in patients with panic disorder with concurrent normal cortisol awakening responses [J].
Petrowski, Katja ;
Herold, Ulf ;
Joraschky, Peter ;
Wittchen, Hans-Ulrich ;
Kirschbaum, Clemens .
PSYCHONEUROENDOCRINOLOGY, 2010, 35 (03) :414-421
[64]   Association between posttraumatic stress disorder and inflammation: A twin study [J].
Plantinga, Laura ;
Bremner, J. Douglas ;
Miller, Andrew H. ;
Jones, Dean P. ;
Veledar, Emir ;
Goldberg, Jack ;
Vaccarino, Viola .
BRAIN BEHAVIOR AND IMMUNITY, 2013, 30 :125-132
[65]   Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response [J].
Powell, Timothy R. ;
Schalkwyk, Leonard C. ;
Heffernan, Andrew L. ;
Breen, Gerome ;
Lawrence, Timothy ;
Price, Tom ;
Farmer, Anne E. ;
Aitchison, Katherine J. ;
Craig, Ian W. ;
Danese, Andrea ;
Lewis, Cathryn ;
McGuffin, Peter ;
Uher, Rudolf ;
Tansey, Katherine E. ;
D'Souza, Ursula M. .
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2013, 23 (09) :1105-1114
[66]   A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression [J].
Raison, Charles L. ;
Rutherford, Robin E. ;
Woolwine, Bobbi J. ;
Shuo, Chen ;
Schettler, Pamela ;
Drake, Daniel F. ;
Haroon, Ebrahim ;
Miller, Andrew H. .
JAMA PSYCHIATRY, 2013, 70 (01) :31-41
[67]   Hypothalamus-Pituitary-Adrenal Axis Hyperresponsiveness Is Associated with Increased Social Avoidance Behavior in Social Phobia [J].
Roelofs, Karin ;
van Peer, Jacobien ;
Berretty, Ed ;
de Jong, Paula ;
Spinhoven, Philip ;
Elzinga, Bernet M. .
BIOLOGICAL PSYCHIATRY, 2009, 65 (04) :336-343
[68]   Cortisol levels in response to starting school in children at increased risk for social phobia [J].
Russ, Stephanie J. ;
Herbert, Joe ;
Cooper, Peter ;
Gunnar, Megan R. ;
Goodyer, Ian ;
Croudace, Tim ;
Murray, Lynne .
PSYCHONEUROENDOCRINOLOGY, 2012, 37 (04) :462-474
[69]   The relationship between anxiety disorders and physical disorders in the US National Comorbidity Survey [J].
Sareen, J ;
Cox, BJ ;
Clara, I ;
Asmundson, GJG .
DEPRESSION AND ANXIETY, 2005, 21 (04) :193-202
[70]   Cortisol levels and longitudinal cortisol change as predictors of anxiety in adolescents [J].
Schiefelbein, Virginia L. ;
Susman, Elizabeth J. .
JOURNAL OF EARLY ADOLESCENCE, 2006, 26 (04) :397-413
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