Neuroinflammatory pathways in anxiety, posttraumatic stress, and obsessive compulsive disorders

被引：125

作者：

Furtado, Melissa ^{[1
]}

Katzman, Martin A. ^{[1
,2
,3
,4
,5
]}

机构：

[1] START Clin Mood & Anxiety Disorders, Toronto, ON M4W 2N4, Canada

[2] Univ Toronto, Fac Med, Dept Psychiat, Toronto, ON M5S 1A1, Canada

[3] Northern Ontario Sch Med, Thunder Bay, ON, Canada

[4] Lakehead Univ, Dept Psychol, Thunder Bay, ON P7B 5E1, Canada

[5] Adler Grad Profess Sch, Toronto, ON, Canada

来源：

PSYCHIATRY RESEARCH | 2015年 / 229卷 / 1-2期

关键词：

Generalized anxiety disorder; Social anxiety disorder; Panic disorder; Posttraumatic stress disorder; Obsessive compulsive disorder; Inflammation; Hypothalamic pituitary adrenal axis; C-REACTIVE PROTEIN; PITUITARY-ADRENAL ACTIVITY; TUMOR-NECROSIS-FACTOR; GENERALIZED ANXIETY; SALIVARY CORTISOL; HAIR CORTISOL; TNF-ALPHA; HPA AXIS; DEPRESSIVE SYMPTOMS; PHYSICAL DISORDERS;

D O I：

10.1016/j.psychres.2015.05.036

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

As prevalence of anxiety, posttraumatic stress, and obsessive compulsive disorders continue to rise worldwide, increasing focus has been placed on immune mediated theories in understanding the underlying mechanisms of these disorders. Associations between the dysregulation of the hypothalamic pituitary adrenal (HPA) axis and these disorders have been recognized in the scientific literature, specifically in regard to cortisol levels, as well as changes in pro- and anti-inflammatory cytokines. The present commentary will systematically assess the scientific literature within the past decade in regard to the psychoneuroimmunology of anxiety, posttraumatic stress, and obsessive compulsive disorders. Understanding the mechanisms of these disorders is essential in order to determine efficacious and targeted treatment strategies, which may lead to substantial improvements in overall functioning, as well as significant decreases in societal and economic burden. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：37 / 48

页数：12

共 89 条

[11] Generalized anxiety and C-reactive protein levels: a prospective, longitudinal analysis [J].

Copeland, W. E. ;

Shanahan, L. ;

Worthman, C. ;

Angold, A. ;

Costello, E. J. .

PSYCHOLOGICAL MEDICINE, 2012, 42 (12) :2641-2650

[12] Deep brain stimulation for obsessive-compulsive disorder is associated with cortisol changes [J].

de Koning, Pelle P. ;

Figee, Martijn ;

Endert, Erik ;

Storosum, Jitschak G. ;

Fliers, Eric ;

Denys, Damiaan .

PSYCHONEUROENDOCRINOLOGY, 2013, 38 (08) :1455-1459

[13] Cortisol and PTSD Symptoms Among Male and Female High-Exposure 9/11 Survivors [J].

Dekel, Sharon ;

Ein-Dor, Tsachi ;

Gordon, Kathleen M. ;

Rosen, Jeffrey B. ;

Bonanno, George A. .

JOURNAL OF TRAUMATIC STRESS, 2013, 26 (05) :621-625

[14] Effects of paroxetine and venlafaxine on immune parameters in patients with obsessive compulsive disorder [J].

Denys, D ;

Fluitman, S ;

Kavelaars, A ;

Heijnen, C ;

Westenberg, HGM .

PSYCHONEUROENDOCRINOLOGY, 2006, 31 (03) :355-360

[15] Decreased TNF-α and NK activity in obsessive-compulsive disorder [J].

Denys, D ;

Fluitman, S ;

Kavelaars, A ;

Heijnen, C ;

Westenberg, H .

PSYCHONEUROENDOCRINOLOGY, 2004, 29 (07) :945-952

[16] The role of childhood abuse in HPA-axis reactivity in Social Anxiety Disorder: A pilot study [J].

Elzinga, Bernet M. ;

Spinhoven, Philip ;

Berretty, Ed ;

de Jong, Paula ;

Roelofs, Karin .

BIOLOGICAL PSYCHOLOGY, 2010, 83 (01) :1-6

[17] Assessment of Plasma C-Reactive Protein as a Biomarker of Posttraumatic Stress Disorder Risk [J].

Eraly, Satish A. ;

Nievergelt, Caroline M. ;

Maihofer, Adam X. ;

Barkauskas, Donald A. ;

Biswas, Nilima ;

Agorastos, Agorastos ;

O'Connor, Daniel T. ;

Baker, Dewleen G. .

JAMA PSYCHIATRY, 2014, 71 (04) :423-431

[18] Comorbid anxiety and mood disorders among persons with social anxiety disorder [J].

Erwin, BA ;

Heimberg, RG ;

Juster, H ;

Mindlin, M .

BEHAVIOUR RESEARCH AND THERAPY, 2002, 40 (01) :19-35

[19] Childhood stressful events, HPA axis and anxiety disorders [J].

Faravelli, Carlo ;

Lo Sauro, Carolina ;

Godini, Lucia ;

Lelli, Lorenzo ;

Benni, Laura ;

Pietrini, Francesco ;

Lazzeretti, Lisa ;

Talamba, Gabriela Alina ;

Fioravanti, Giulia ;

Ricca, Valdo .

WORLD JOURNAL OF PSYCHIATRY, 2012, 2 (01) :13-25

[20] Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion [J].

Fernandez, Sebastian P. ;

Gaspar, Patricia .

NEUROPHARMACOLOGY, 2012, 62 (01) :144-154

← 1 2 3 4 5 6 7 8 9 →