Association of decreased serum protein fractions with Clostridium difficile infection in the acute care setting: a case-control study

被引：0

作者：

Salazar-Kagunye, Raquel ^{[1
]}

Shah, Anish ^{[1
,2
,3
]}

Loshkajian, Gina ^{[4
]}

Baddoura, Walid ^{[1
,2
,3
]}

DeBari, Vincent A. ^{[1
,5
]}

机构：

[1] St Josephs Reg Med Ctr, Dept Med, Paterson, NJ 07503 USA

[2] St Josephs Reg Med Ctr, Div Gastroenterol, Paterson, NJ USA

[3] Seton Hall Univ, Sch Hlth & Med Sci, Div Gastroenterol, S Orange, NJ 07079 USA

[4] St Georges Univ, Sch Med, St Georges, Grenada

[5] Seton Hall Univ, Sch Hlth & Med Sci, Dept Med, S Orange, NJ 07079 USA

来源：

BIOMARKERS IN MEDICINE | 2012年 / 6卷 / 05期

关键词：

albumin; biomarker; Clostridium difficile; colitis; diarrhea; globulin; nosocomial infection; serum protein; CHANGING EPIDEMIOLOGY; RISK-FACTORS; DIARRHEA; COLITIS; SEVERITY; DISEASE;

D O I：

10.2217/BMM.12.52

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: This study examines the association of decreased levels of serum proteins with the occurrence of Clostridium difficile-associated diarrhea (CDAD) in hospitalized patients. Materials & methods: This is a retrospective case control study using a case cohort (n = 171) that had been described in an earlier study and a cohort of 332 contemporaneous controls. Results: Patients with CDAD had significantly lower serum levels of albumin, total protein and globulins, and decreased albumin/globulin ratio (p < 0.0001 for all parameters). After adjustment for confounders, hypoproteinemia was more closely associated with CDAD than either hypoalbuminemia or albumin/globulin ratio. Hypoproteinemia exhibited an odds ratios of 10.6 (95% CI: 6.62-17.0) after adjustment for race, and 11.0 (95% CI: 6.88-17.1) after adjustment for age. Conclusion: Decreased total serum protein is more closely associated with CDAD than hypoalbuminemia.

引用

页码：663 / 669

页数：7

共 20 条

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