Temporal dynamics of lactate concentration in the human brain during acute inspiratory hypoxia

被引:17
作者
Harris, Ashley D. [1 ]
Roberton, Victoria H. [1 ]
Huckle, Danielle L. [2 ]
Saxena, Neeraj [2 ]
Evans, C. John [1 ]
Murphy, Kevin [1 ]
Hall, Judith E. [2 ]
Bailey, Damian M. [3 ]
Mitsis, Georgios [4 ]
Edden, Richard A. E. [1 ,5 ,6 ]
Wise, Richard G. [1 ]
机构
[1] Cardiff Univ, Brain Imaging Res Ctr, Sch Psychol, Cardiff CF10 3AT, S Glam, Wales
[2] Cardiff Univ, Dept Anaesthet, Cardiff CF10 3AT, S Glam, Wales
[3] Univ Glamorgan, Dept Hlth Sport & Sci, Pontypridd CF37 1DL, M Glam, Wales
[4] Univ Cyprus, Dept Elect & Comp Engn, Nicosia, Cyprus
[5] Johns Hopkins Univ, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA
[6] Kennedy Krieger Inst, FM Kirby Res Ctr Funct Brain Imaging, Baltimore, MD USA
基金
加拿大自然科学与工程研究理事会; 英国惠康基金; 美国国家卫生研究院; 英国医学研究理事会;
关键词
lactate; cerebral lactate; magnetic resonance spectroscopy; hypoxia; neuroimaging; impulse response function; BLOOD-FLOW; ENERGY-METABOLISM; VISUAL-CORTEX; IN-VIVO; SPECTROSCOPY; ACTIVATION; RATIO;
D O I
10.1002/jmri.23815
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To demonstrate the feasibility of measuring the temporal dynamics of cerebral lactate concentration and examine these dynamics in human subjects using magnetic resonance spectroscopy (MRS) during hypoxia. Materials and Methods: A respiratory protocol consisting of 10-minute baseline normoxia, 20-minute inspiratory hypoxia, and ending with 10-minute normoxic recovery was used, throughout which lactate-edited MRS was performed. This was repeated four times in three subjects. A separate session was performed to measure blood lactate. Impulse response functions using end-tidal oxygen and blood lactate as system inputs and cerebral lactate as the system output were examined to describe the dynamics of the cerebral lactate response to a hypoxic challenge. Results: The average lactate increase was 20% +/- 15% during the last half of the hypoxic challenge. Significant changes in cerebral lactate concentration were observed after 400 seconds. The average relative increase in blood lactate was 188% +/- 95%. The temporal dynamics of cerebral lactate concentration was reproducibly demonstrated with 200-second time bins of MRS data (coefficient of variation 0.063 +/- 0.035 between time bins in normoxia). The across-subject coefficient of variation was 0.333. Conclusion: The methods for measuring the dynamics of the cerebral lactate response developed here would be useful to further investigate the brain's response to hypoxia. J. Magn. Reson. Imaging 2013;37:739745. (c) 2012 Wiley Periodicals, Inc.
引用
收藏
页码:739 / 745
页数:7
相关论文
共 23 条
[1]   ANALYSIS OF MACROMOLECULE RESONANCES IN H-1-NMR SPECTRA OF HUMAN BRAIN [J].
BEHAR, KL ;
ROTHMAN, DL ;
SPENCER, DD ;
PETROFF, OAC .
MAGNETIC RESONANCE IN MEDICINE, 1994, 32 (03) :294-302
[2]   Gray matter blood flow change is unevenly distributed during moderate isocapnic hypoxia in humans [J].
Binks, Andrew P. ;
Cunningham, Vincent J. ;
Adams, Lewis ;
Banzett, Robert B. .
JOURNAL OF APPLIED PHYSIOLOGY, 2008, 104 (01) :212-217
[3]   The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic 13C Nuclear Magnetic Resonance Spectroscopy [J].
Boumezbeur, Fawzi ;
Petersen, Kitt F. ;
Cline, Gary W. ;
Mason, Graeme F. ;
Behar, Kevin L. ;
Shulman, Gerald I. ;
Rothman, Douglas L. .
JOURNAL OF NEUROSCIENCE, 2010, 30 (42) :13983-13991
[4]   The metabolism of [3-13C]lactate in the rat brain is specific of a pyruvate carboxylase-deprived compartment [J].
Bouzier, AK ;
Thiaudiere, E ;
Biran, M ;
Rouland, R ;
Canioni, P ;
Merle, M .
JOURNAL OF NEUROCHEMISTRY, 2000, 75 (02) :480-486
[5]   Changes of cerebral blood flow during short-term exposure to normobaric hypoxia [J].
Buck, A ;
Schirlo, C ;
Jasinsky, V ;
Weber, B ;
Burger, C ;
von Schulthess, GK ;
Koller, EA ;
Pavlicek, V .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1998, 18 (08) :906-910
[6]   A reduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the human brain [J].
Dalsgaard, MK ;
Quistorff, B ;
Danielsen, ER ;
Selmer, C ;
Vogelsang, T ;
Secher, NH .
JOURNAL OF PHYSIOLOGY-LONDON, 2004, 554 (02) :571-578
[7]   Brain lactate metabolism: the discoveries and the controversies [J].
Dienel, Gerald A. .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2012, 32 (07) :1107-1138
[8]   Edited MRS Is Sensitive to Changes in Lactate Concentration During Inspiratory Hypoxia [J].
Edden, Richard A. E. ;
Harris, Ashley D. ;
Murphy, Kevin ;
Evans, C. John ;
Saxena, Neeraj ;
Hall, Judith E. ;
Bailey, Damian M. ;
Wise, Richard G. .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2010, 32 (02) :320-325
[9]   Sustained neuronal activation raises oxidative metabolism to a new steady-state level:: evidence from 1H NMR spectroscopy in the human visual cortex [J].
Mangia, Silvia ;
Tkac, Ivan ;
Gruetter, Rolf ;
Van de Moortele, Pierre-Francois ;
Maraviglia, Bruno ;
Ugurbil, Kamil .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2007, 27 (05) :1055-1063
[10]   IDENTIFICATION OF NONLINEAR BIOLOGICAL-SYSTEMS USING LAGUERRE EXPANSIONS OF KERNELS [J].
MARMARELIS, VZ .
ANNALS OF BIOMEDICAL ENGINEERING, 1993, 21 (06) :573-589