Sleep Disturbance and Incidence of Thyroid Cancer in Postmenopausal Women The Women's Health Initiative

被引:67
|
作者
Luo, Juhua [1 ]
Sands, Megan [2 ]
Wactawski-Wende, Jean [3 ]
Song, Yiqing [4 ]
Margolis, Karen L. [5 ]
机构
[1] W Virginia Univ, Dept Community Med, Robert C Byrd Hlth Sci Ctr, Mary Babb Randolph Canc Ctr,Sch Med, Morgantown, WV 26506 USA
[2] Univ Penn, Ctr Sleep & Circadian Neurobiol, Perelman Sch Med, Philadelphia, PA 19104 USA
[3] SUNY Buffalo, Dept Social & Prevent Med, Sch Publ Hlth & Hlth Profess, Buffalo, NY 14260 USA
[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Prevent Med,Dept Med,BWH Biomed Res Inst, Boston, MA 02115 USA
[5] Hlth Partners Res Fdn, Minneapolis, MN USA
基金
美国国家卫生研究院;
关键词
insomnia; sleep disorder; sleep disturbance; risk factors; thyroid cancer; BASE-LINE CHARACTERISTICS; NIGHT-SHIFT WORK; SERUM THYROTROPIN CONCENTRATION; BREAST-CANCER; COLORECTAL-CANCER; RISK-FACTORS; DURATION; INSOMNIA; RELIABILITY; MALIGNANCY;
D O I
10.1093/aje/kws193
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Sleep disturbance has been found to be associated with numerous adverse health outcomes, including cancers. However, no epidemiologic study has examined the relation between sleep disturbance and thyroid cancer risk. A total of 142,933 postmenopausal women who were 5079 years of age and enrolled in the Womens Health Initiative between September 1, 1993, and December 31, 1998, were followed up for a mean of 11 years. Cox proportional-hazard regression models were used to estimate hazard ratios and 95 confidence intervals for sleep disturbance (insomnia and sleep duration) and risk of thyroid cancer. Insomnia score was measured using a validated 5-item Womens Health Initiative Insomnia Rating Scale. Overall, a total of 295 thyroid cancer cases were identified. After adjustment for potential confounders, women with greater insomnia scores had a significantly higher risk of thyroid cancer than did women with low scores (hazard ratio 1.44, 95 confidence interval: 1.01, 2.05). The significant association between insomnia score and thyroid cancer was confined to nonobese women (hazard ratio 1.71, 95 confidence interval: 1.12, 2.62) and was not seen in obese women (hazard ratio 0.94 95 confidence interval: 0.48, 1.84) (P for interaction 0.07). In conclusion, postmenopausal women with greater insomnia scores, especially nonobese women, had a significantly increased risk of thyroid cancer. More studies are needed to confirm these findings.
引用
收藏
页码:42 / 49
页数:8
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