Homoharringtonine Induces Apoptosis in Human Colorectal Carcinoma HCT116 Cells Via Downregulation of Wnt/β-Catenin Signaling Cascade

被引：5
作者：
Park, Mikyung [1 ,2 ]
Kwon, Ho Jeong [2 ]
Kim, Seong Hwan [1 ]
机构：
[1] Korea Res Inst Chem Technol, Innovat Target Res Ctr, Bio & Drug Discovery Div, Daejeon 34114, South Korea
[2] Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Chem Genom GRL, Seoul 03722, South Korea
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2019年 / 40卷 / 02期
关键词：
Homoharringtonine; Wnt; beta-Catenin; Porcupine; Colon cancer; CHRONIC MYELOID-LEUKEMIA; BETA-CATENIN; PROTEIN-SYNTHESIS; CANCER CELLS; LUNG-CANCER; CYCLIN D1; INHIBITION; PORCUPINE; ACTIVATION; EXPRESSION;
D O I：
10.1002/bkcs.11662
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[No abstract available]
引用
收藏
页码：196 / 199
页数：4
相关论文
共 50 条
  • [21] Triptolide induces apoptosis of breast cancer cells via a mechanism associated with the Wnt/β-catenin signaling pathway
    Shao, Hongmin
    Ma, Jinghua
    Guo, Tianhua
    Hu, Rongrong
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2014, 8 (02) : 505 - 508
  • [22] Ursolic acid inhibits proliferation and induces apoptosis by inactivating Wnt/β-catenin signaling in human osteosarcoma cells
    Zhang, Ran-Xi
    Li, Yang
    Tian, Dong-Dong
    Liu, Yang
    Nian, Wu
    Zou, Xiang
    Chen, Qian-Zhao
    Zhou, Lin-Yun
    Deng, Zhong-Liang
    He, Bai-Cheng
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2016, 49 (05) : 1973 - 1982
  • [23] Icariin inhibits growth of human osteosarcoma cells by inducing apoptosis via downregulation of β-catenin signaling
    Tie, Hongtao
    Kuang, Ge
    Gong, Xia
    Jiang, Rong
    Wan, Jingyuan
    Wang, Bin
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 9 (08): : 15437 - 15446
  • [24] Curcumin Inhibits Gastric Carcinoma Cell Growth and Induces Apoptosis by Suppressing the Wnt/β-Catenin Signaling Pathway
    Zheng, Ruzhen
    Deng, Qinghua
    Liu, Yuehua
    Zhao, Pengjun
    MEDICAL SCIENCE MONITOR, 2017, 23 : 163 - 171
  • [25] Suppression of HCT116 Human Colon Cancer Cell Motility by Polymethoxyflavones is Associated with Inhibition of Wnt/β-Catenin Signaling
    Hino, Shin-ichiro
    Inenaga, Kiyoka
    Miyazaki, Takuto
    Tanaka-Mizota, Chika
    NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2022, 74 (10): : 3662 - 3669
  • [26] Catalpol promotes cellular apoptosis in human HCT116 colorectal cancer cells via microRNA-200 and the downregulation of PI3K-Akt signaling pathway
    Liu, Lan
    Gao, Hongwei
    Wang, Hongbo
    Zhang, Yuan
    Xu, Weihua
    Lin, Sen
    Wang, Hongjuan
    Wu, Qiong
    Guo, Jianqiang
    ONCOLOGY LETTERS, 2017, 14 (03) : 3741 - 3747
  • [27] Pogostone induces autophagy and apoptosis involving PI3K/Akt/mTOR axis in human colorectal carcinoma HCT116 cells
    Cao, Zhi-Xing
    Yang, Yu-Ting
    Yu, Si
    Li, Yu-Zhi
    Wang, Wen-Wen
    Huang, Jing
    Xie, Xiao-Fang
    Xiong, Liang
    Lei, Song
    Peng, Cheng
    JOURNAL OF ETHNOPHARMACOLOGY, 2017, 202 : 20 - 27
  • [28] Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway
    Xu, Marvin Xuejun
    Zhao, Linlin
    Deng, Chaoyang
    Yang, Lu
    Wang, Yang
    Guo, Tao
    Li, Lifang
    Lin, Jianping
    Zhang, Lirong
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2013, 43 (06) : 1951 - 1959
  • [29] Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells
    Park, Ki-Woong
    Kundu, Juthika
    Chae, In-Gyeong
    Kim, Do-Hee
    Yu, Mi-Hee
    Kundu, Joydeb Kumar
    Chun, Kyung-Soo
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2014, 44 (04) : 1309 - 1315
  • [30] A tannin compound from Sanguisorba officinalis blocks Wnt/β-catenin signaling pathway and induces apoptosis of colorectal cancer cells
    Li, Wa
    Yang, Chun-juan
    Wang, Li-qian
    Wu, Juan
    Dai, Cong
    Yuan, Yue-mei
    Li, George Q.
    Yao, Mei-cun
    CHINESE MEDICINE, 2019, 14 (1)
12345