Homoharringtonine Induces Apoptosis in Human Colorectal Carcinoma HCT116 Cells Via Downregulation of Wnt/β-Catenin Signaling Cascade

被引:5
作者
Park, Mikyung [1 ,2 ]
Kwon, Ho Jeong [2 ]
Kim, Seong Hwan [1 ]
机构
[1] Korea Res Inst Chem Technol, Innovat Target Res Ctr, Bio & Drug Discovery Div, Daejeon 34114, South Korea
[2] Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Chem Genom GRL, Seoul 03722, South Korea
关键词
Homoharringtonine; Wnt; beta-Catenin; Porcupine; Colon cancer; CHRONIC MYELOID-LEUKEMIA; BETA-CATENIN; PROTEIN-SYNTHESIS; CANCER CELLS; LUNG-CANCER; CYCLIN D1; INHIBITION; PORCUPINE; ACTIVATION; EXPRESSION;
D O I
10.1002/bkcs.11662
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:196 / 199
页数:4
相关论文
共 45 条
[1]   A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers [J].
Ahmed, Kamal ;
Shaw, Holly V. ;
Koval, Alexey ;
Katanaev, Vladimir L. .
CANCERS, 2016, 8 (07)
[2]   Linking colorectal cancer to Wnt signaling [J].
Bienz, M ;
Clevers, H .
CELL, 2000, 103 (02) :311-320
[3]   The Soft Agar Colony Formation Assay [J].
Borowicz, Stanley ;
Van Scoyk, Michelle ;
Avasarala, Sreedevi ;
Rathinam, Manoj Kumar Karuppusamy ;
Tauler, Jordi ;
Bikkavilli, Rama Kamesh ;
Winn, Robert A. .
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2014, (92)
[4]   Wnt/β-catenin signaling in development and disease [J].
Clevers, Hans .
CELL, 2006, 127 (03) :469-480
[5]   Discovery and Optimization Of a Porcupine Inhibitor [J].
Duraiswamy, Athisayamani Jeyaraj ;
Lee, May Ann ;
Madan, Babita ;
Ang, Shi Hua ;
Tan, Eldwin Sum Wai ;
Cheong, Wei Wen Vivien ;
Ke, Zhiyuan ;
Pendharkar, Vishal ;
Ding, Li Jun ;
Chew, Yun Shan ;
Manoharan, Vithya ;
Sangthongpitag, Kanda ;
Alam, Jenefer ;
Poulsen, Anders ;
Ho, Soo Yei ;
Virshup, David M. ;
Keller, Thomas H. .
JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (15) :5889-5899
[6]   Activation of tumor-specific splice variant Rac1b by dishevelled promotes canonical Wnt signaling and decreased adhesion of colorectal cancer cells [J].
Esufali, Susmita ;
Charames, George S. ;
Pethe, Vaijayanti V. ;
Buongiorno, Pinella ;
Bapat, Bharati .
CANCER RESEARCH, 2007, 67 (06) :2469-2479
[7]   The use of porcupine inhibitors to target Wnt-driven cancers [J].
Ho, Soo Yei ;
Keller, Thomas H. .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (23) :5472-5476
[8]   beta-Catenin mutations in cell lines established from human colorectal cancers [J].
Ilyas, M ;
Tomlinson, IPM ;
Rowan, A ;
Pignatelli, M ;
Bodmer, WF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (19) :10330-10334
[9]   Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy [J].
Kendziorra, Emil ;
Ahlborn, Kerstin ;
Spitzner, Melanie ;
Rave-Fraenk, Margret ;
Emons, Georg ;
Gaedcke, Jochen ;
Kramer, Frank ;
Wolff, Hendrik A. ;
Becker, Heinz ;
Beissbarth, Tim ;
Ebner, Reinhard ;
Ghadimi, B. Michael ;
Pukrop, Tobias ;
Ried, Thomas ;
Grade, Marian .
CARCINOGENESIS, 2011, 32 (12) :1824-1831
[10]  
Kobayashi M, 2000, BRIT J CANCER, V82, P1689