The Effects of Comorbid Obsessive-Compulsive Disorder and Attention-Deficit Hyperactivity Disorder on Quality of Life in Tourette Syndrome

被引:53
作者
Eddy, Clare M. [1 ,2 ]
Cavanna, Andrea E. [1 ,3 ]
Gulisano, Mariangela [4 ,5 ]
Cali, Paola [4 ,5 ]
Robertson, Mary M. [6 ,7 ]
Rizzo, Renata [4 ,5 ]
机构
[1] Univ Birmingham, BSMHFT, Dept Neuropsychiat, Michael Trimble Neuropsychiat Res Grp, Birmingham, W Midlands, England
[2] Univ Birmingham, Sch Clin & Expt Med, Birmingham, W Midlands, England
[3] UCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London, England
[4] Catania Univ, Dept Pediat, Sect Child Neuropsychiat, Catania, Italy
[5] Catania Univ, Dept Biomed Sci, Catania, Italy
[6] St George Hosp, Sch Med, London, England
[7] UCL, Dept Mental Hlth Sci, London, England
关键词
YOUNG-PEOPLE; CHILDREN; SCALE; RELIABILITY; VALIDATION; VALIDITY; ANXIETY; IMPACT; ADHD; QOL;
D O I
10.1176/appi.neuropsych.11080181
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Tourette syndrome (TS) is a complex neuropsychiatric disorder affecting patients' quality of life (QoL). The authors compared QoL measures in young patients with "pure" TS (without comorbid conditions) versus those with TS+OCD (obsessive-compulsive disorder), TS+ADHD (attention-deficit hyperactivity disorder), or TS+OCD+ADHD. Age and scores on scales assessing tic severity, depression, anxiety, and behavioral problems were included as covariates. Young patients with both comorbidities exhibited significantly lower Total and Relationship Domain QoL scores, versus patients with pure TS. Across the whole sample, high ADHD-symptom scores were related to poorer QoL within the Self and Relationship domains, whereas high OCD symptom scores were associated with more widespread difficulties across the Self, Relationship, Environment, and General domains. Significant differences in QoL may be most likely when both comorbidities are present, and features of OCD and ADHD may have different impacts on QoL across individual domains. (The Journal of Neuropsychiatry and Clinical Neurosciences 2012; 24:458-462)
引用
收藏
页码:458 / 462
页数:5
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