Pseudorabies Virus Fast Axonal Transport Occurs by a pUS9-Independent Mechanism

被引：25
作者：
Daniel, Gina R. [1 ]
Sollars, Patricia J. [2 ]
Pickard, Gary E. [2 ]
Smith, Gregory A. [1 ]
机构：
[1] Northwestern Univ, Dept Microbiol Immunol, Chicago, IL 60611 USA
[2] Univ Nebraska, Sch Vet Med & Biomed Sci, Lincoln, NE USA
来源：
JOURNAL OF VIROLOGY | 2015年 / 89卷 / 15期
基金：
美国国家卫生研究院;
关键词：
HERPES-SIMPLEX-VIRUS; PROMOTE TRANSPORT; US9; INFECTION; PROTEINS; SPREAD; GLYCOPROTEINS; NEUROINVASION; INJECTION; STRAINS;
D O I：
10.1128/JVI.00771-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Reactivation from latency results in transmission of neurotropic herpesviruses from the nervous system to body surfaces, referred to as anterograde axonal trafficking. The virus-encoded protein pUS9 promotes axonal dissemination by sorting virus particles into axons, but whether it is also an effector of fast axonal transport within axons is unknown. To determine the role of pUS9 in anterograde trafficking, we analyzed the axonal transport of pseudorabies virus in the presence and absence of pUS9.
引用
收藏
页码：8088 / 8091
页数：4
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