The NaV1.7 sodium channel: from molecule to man

被引：436
作者：
Dib-Hajj, Sulayman D. [1 ,2 ,3 ]
Yang, Yang [1 ,2 ,3 ]
Black, Joel A. [1 ,2 ,3 ]
Waxman, Stephen G. [1 ,2 ,3 ]
机构：
[1] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Ctr Neurosci & Regenerat Res, New Haven, CT 06510 USA
[3] Vet Affairs Connecticut Healthcare Syst, Rehabil Res Ctr, West Haven, CT 06516 USA
来源：
NATURE REVIEWS NEUROSCIENCE | 2013年 / 14卷 / 01期
关键词：
VOLTAGE-GATED SODIUM; EXTREME PAIN DISORDER; CLOSED-STATE INACTIVATION; OF-FUNCTION MUTATIONS; ROOT GANGLION NEURONS; NEUROPATHIC PAIN; SENSORY NEURONS; ELECTROPHYSIOLOGICAL PROPERTIES; SLOW-INACTIVATION; PHARMACOLOGICAL MANAGEMENT;
D O I：
10.1038/nrn3404
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The voltage-gated sodium channel Na(V)1.7 is preferentially expressed in peripheral somatic and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion neurons. Na(V)1.7 accumulates at nerve fibre endings and amplifies small subthreshold depolarizations, poising it to act as a threshold channel that regulates excitability. Genetic and functional studies have added to the evidence that Na(V)1.7 is a major contributor to pain signalling in humans, and homology modelling based on crystal structures of ion channels suggests an atomic-level structural basis for the altered gating of mutant Na(V)1.7 that causes pain.
引用
收藏
页码：49 / 62
页数：14
相关论文
共 141 条
[71]   Functional profiles of SCN9A variants in dorsal root ganglion neurons and superior cervical ganglion neurons correlate with autonomic symptoms in small fibre neuropathy [J].
Han, Chongyang ;
Hoeijmakers, Janneke G. J. ;
Liu, Shujun ;
Gerrits, Monique M. ;
te Morsche, Rene H. M. ;
Lauria, Giuseppe ;
Dib-Hajj, Sulayman D. ;
Drenth, Joost P. H. ;
Faber, Catharina G. ;
Merkies, Ingemar S. J. ;
Waxman, Stephen G. .
BRAIN, 2012, 135 :2613-2628
[72]   Early- and late-onset inherited erythromelalgia: genotypephenotype correlation [J].
Han, Chongyang ;
Dib-Hajj, Sulayman D. ;
Lin, Zhimiao ;
Li, Yan ;
Eastman, Emmanuella M. ;
Tyrrell, Lynda ;
Cao, Xianwei ;
Yang, Yong ;
Waxman, Stephen G. .
BRAIN, 2009, 132 :1711-1722
[73]   Lacosamide, a new anti-epileptic, alleviates neuropathic pain-like behaviors in rat models of spinal cord or trigeminal nerve injury [J].
Hao, Jing-Xia ;
Stoehr, Thomas ;
Selve, Norma ;
Wiesenfeld-Hallin, Zsuzsanna ;
Xu, Xiao-Jun .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 553 (1-3) :135-140
[74]   Nav1.7 mutant A863P in erythromelalgia:: Effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons [J].
Harty, T. Patrick ;
Dib-Hajj, Sulayman D. ;
Tyrrell, Lynda ;
Blackman, Rachael ;
Hisama, Fuki M. ;
Rose, John B. ;
Waxman, Stephen G. .
JOURNAL OF NEUROSCIENCE, 2006, 26 (48) :12566-12575
[75]   Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons [J].
Herzog, RI ;
Cummins, TR ;
Ghassemi, F ;
Dib-Hajj, SD ;
Waxman, SG .
JOURNAL OF PHYSIOLOGY-LONDON, 2003, 551 (03) :741-750
[76]   Tetrodotoxin-sensitive Na+ channels and muscarinic and purinergic receptors identified in human erythroid progenitor cells and red blood cell ghosts [J].
Hoffman, JF ;
Dodson, A ;
Wickrema, A ;
Dib-Hajj, SD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (33) :12370-12374
[77]   Sodium current in human jejunal circular smooth muscle cells [J].
Holm, AN ;
Rich, A ;
Miller, SM ;
Strege, P ;
Ou, YJ ;
Gibbons, SJ ;
Sarr, MG ;
Szurszewski, JH ;
Rae, JL ;
Farrugia, G .
GASTROENTEROLOGY, 2002, 122 (01) :178-187
[78]   Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents [J].
Jarecki, Brian W. ;
Piekarz, Andrew D. ;
Jackson, James O., II ;
Cummins, Theodore R. .
JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (01) :369-378
[79]   The open pore conformation of potassium channels [J].
Jiang, YX ;
Lee, A ;
Chen, JY ;
Cadene, M ;
Chait, BT ;
MacKinnon, R .
NATURE, 2002, 417 (6888) :523-526
[80]   Voltage-gated sodium channel expressed in cultured human smooth muscle cells: involvement of SCN9A [J].
Jo, T ;
Nagata, T ;
Iida, H ;
Imuta, H ;
Iwasawa, K ;
Ma, J ;
Hara, K ;
Omata, M ;
Nagai, R ;
Takizawa, H ;
Nagase, T ;
Nakajima, T .
FEBS LETTERS, 2004, 567 (2-3) :339-343
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