Treatment of Radiation-Induced Cognitive Decline in Adult Brain Tumor Patients

被引：41

作者：

Cramer, Christina K. ^{[1
]}

Cummings, Tiffany L. ^{[2
]}

Andrews, Rachel N. ^{[3
]}

Strowd, Roy ^{[4
]}

Rapp, Stephen R. ^{[5
,6
]}

Shaw, Edward G. ^{[7
]}

Chan, Michael D. ^{[1
]}

Lesser, Glenn J. ^{[8
]}

机构：

[1] Wake Forest Baptist Med Ctr, Dept Radiat Oncol, Med Ctr Blvd, Winston Salem, NC 27157 USA

[2] Wake Forest Baptist Med Ctr, Dept Neurol, Winston Salem, NC 27157 USA

[3] Wake Forest Baptist Med Ctr, Dept Radiat Oncol, Sect Radiat Biol, Med Ctr Blvd, Winston Salem, NC 27157 USA

[4] Wake Forest Baptist Med Ctr, Dept Hematol Oncol, Winston Salem, NC 27157 USA

[5] Wake Forest Sch Med, Dept Psychiat & Behav Med, Med Ctr Blvd, Winston Salem, NC USA

[6] Wake Forest Sch Med, Div Publ Hlth Sci Social Sci & Hlth Policy, Med Ctr Blvd, Winston Salem, NC USA

[7] Wake Forest Baptist Hlth, Memory Counseling Program, Sect Gerontol & Geriatr Med, Sticht Ctr Hlth Aging & Alzheimers Prevent, Med Ctr Blvd, Winston Salem, NC 27157 USA

[8] Wake Forest Baptist Comprehens Canc Ctr, Oncol, Med Neurooncol & Neurooncol Res Program, Med Ctr Blvd, Winston Salem, NC 27157 USA

来源：

CURRENT TREATMENT OPTIONS IN ONCOLOGY | 2019年 / 20卷 / 05期

关键词：

Cognition; Brain; Radiation; Neuropsychology; Memory; Attention; NF-KAPPA-B; ALZHEIMERS ASSOCIATION WORKGROUPS; OLIGODENDROCYTE PROGENITOR CELLS; WHITE-MATTER HYPERINTENSITIES; DOUBLE-BLIND; PHASE-III; HIPPOCAMPAL NEUROGENESIS; X-IRRADIATION; NEUROCOGNITIVE FUNCTION; DIAGNOSTIC GUIDELINES;

D O I：

10.1007/s11864-019-0641-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with either primary or metastatic brain tumors quite often have cognitive impairment. Maintaining cognitive function is important to brain tumor patients and a decline in cognitive function is generally accompanied by a decline in functional independence and performance status. Cognitive decline can be a result of tumor progression, depression/anxiety, fatigue/sleep dysfunction, or the treatments they have received. It is our opinion that providers treating brain tumor patients should obtain pre-treatment and serial cognitive testing in their patients and offer mitigating and therapeutic interventions when appropriate. They should also support cognition-focused clinical trials. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

引用

页数：16

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