Porcine circovirus type 2 infection before and during an outbreak of postweaning multisystemic wasting syndrome on a pig farm in the UK

被引：7

作者：

Wieland, B. ^{[1
]}

Werling, D. ^{[1
]}

Nevel, A. ^{[1
]}

Grierson, S. ^{[2
]}

Rycroft, A. ^{[1
]}

Demmers, T. G. ^{[1
]}

Cook, A. J. C. ^{[2
]}

Done, S. H. ^{[3
]}

Armstrong, D. ^{[4
]}

Wathes, C. M. ^{[1
]}

机构：

[1] Univ London Royal Vet Coll, London, England

[2] AHVLA, Weybridge, Surrey, England

[3] AHVLA, Thirsk, N Yorkshire, England

[4] BPEX Ltd, Kenilworth, Warwick, England

来源：

VETERINARY RECORD | 2012年 / 170卷 / 23期

基金：

英国生物技术与生命科学研究理事会;

关键词：

PMWS-AFFECTED FARMS; RISK-FACTORS; GENOTYPE DEFINITION; WEANED PIGS; PCV2; DNA; ANTIBODIES; DISEASE; LESIONS; HERDS; SWINE;

D O I：

10.1136/vr.100276

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The presence of porcine circovirus type 2 (PCV-2) and other pathogens before and during an outbreak of postweaning multisystemic wasting syndrome (PWMS) in pigs is evaluated in this study. At the time of the outbreak on a large commercial pig farm in the UK, serum samples and data were collected in two independent on-going research projects, one in weaned pigs and the other in sows. Serum samples of growing pigs and sows were PCV-2-antibody and PCR positive before and during the PMWS outbreak. Upon sequencing, PCV-2 isolates collected before the outbreak were identified as PCV-2a, and isolates collected during the outbreak were identified as PCV-2b, suggesting a shift of PCV-2 genotypes present on the farm. Pigs in the weaner study were from sows originating from different breeders and an association of sow origin and PCV-2 serostatus in offspring was found. Further, pigs had higher odds to be PCV-2 antigen positive if the sow was PCV-2 antibody positive around farrowing, the sow was of higher parity, and were less likely to test antigen positive if the sow was sourced from a particular breeder. The findings of this study highlight the potential role of the immune status of the sow on the occurrence of PMWS.

引用

页码：596 / +

页数：7

共 47 条

[1]

Allan G, 1998, VET REC, V142, P467

[2] Porcine circovirus 2 replication in colostrum-deprived piglets following experimental infection and immune stimulation using a modified live vaccine against porcine respiratory and reproductive syndrome virus [J].