Changes in the Levels of N-Cadherin and PCNA in Skin Melanoma Cells Are Mediated through Matrix Metalloproteinase 9

被引：1

作者：

Aksenenko, M. B. ^{[1
]}

Gyrylova, S. N. ^{[1
]}

Ruksha, T. G. ^{[1
]}

机构：

[1] VF Voino Yasenetsky State Med Univ, VV Ivanov Dept Pathophysiol, Clin Pathophysiol Course, Krasnoyarsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 153卷 / 03期

关键词：

matrix metalloproteinase 9; skin melanoma; N-cadherin; MATRIX METALLOPROTEINASES; PROLIFERATION; MMP-9;

D O I：

10.1007/s10517-012-1717-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Immunohistochemical studies revealed increased level of matrix metalloproteinase 9 in skin melanoma cells. Inhibition of matrix metalloproteinase 9 with interfering RNA changed the level of PCNA and reduced N-cadherin content in melanoma cells. This attests to the involvement of matrix metalloproteinase 9 in the realization of invasion and metastatic growth and in the regulation of tumor growth and progress.

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页码：364 / 366

页数：3

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