Eculizumab treatment efficiently prevents C5 cleavage without C5a generation in vivo

被引：18

作者：

Volokhina, Elena B. ^{[1
]}

Bergseth, Grethe ^{[2
]}

van de Kar, Nicole C. A. J. ^{[1
]}

van den Heuvel, Lambertus P. ^{[1
,3
,4
]}

Mollnes, Tom Eirik ^{[2
,5
,6
,7
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Pediat Nephrol, NL-6525 ED Nijmegen, Netherlands

[2] Nordland Hosp, Res Lab, NO-8092 Bodo, Norway

[3] Radboud Univ Nijmegen, Med Ctr, Dept Lab Med, NL-6525 ED Nijmegen, Netherlands

[4] Univ Hosp, Dept Pediat Nephrol, Leuven, Belgium

[5] Univ Oslo, Oslo Univ Hosp, KG Jebsen Inflammat Res Ctr, Dept Immunol, Oslo, Norway

[6] Univ Tromso, Fac Hlth Sci, KG Jebsen Thrombosis Res & Expertise Ctr, Tromso, Norway

[7] Norwegian Univ Sci & Technol, Ctr Mol Inflammat Res, N-7034 Trondheim, Norway

来源：

BLOOD | 2015年 / 126卷 / 02期

关键词：

HUMAN-COMPLEMENT; ACTIVATION; PRODUCTS;

D O I：

10.1182/blood-2015-03-637645

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：278 / 279

页数：2

共 8 条

[1] An international serum standard for application in assays to detect human complement activation products [J].

Bergseth, Grethe ;

Ludviksen, Judith K. ;

Kirschfink, Michael ;

Giclas, Patricia C. ;

Nilsson, Bo ;

Mollnes, Tom E. .

MOLECULAR IMMUNOLOGY, 2013, 56 (03) :232-239

[2] Eculizumab fails to inhibit generation of C5a in vivo [J].

Burwick, Richard M. ;

Burwick, Nicholas R. ;

Feinberg, Bruce B. .

BLOOD, 2014, 124 (23) :3502-3503

[3] FLUID PHASE GENERATION OF TERMINAL COMPLEMENT COMPLEX AS A NOVEL INDEX OF BIOINCOMPATIBILITY [J].

DEPPISCH, R ;

SCHMITT, V ;

BOMMER, J ;

HANSCH, GM ;

RITZ, E ;

RAUTERBERG, EW .

KIDNEY INTERNATIONAL, 1990, 37 (02) :696-706

[4] Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn [J].

Hallstensen, Randi Fykse ;

Bergseth, Grethe ;

Foss, Stian ;

Jaeger, Steinar ;

Gedde-Dahl, Tobias ;

Holt, Jan ;

Christiansen, Dorte ;

Lau, Corinna ;

Brekke, Ole-Lars ;

Armstrong, Elina ;

Stefanovic, Vedran ;

Andersen, Jan Terje ;

Sandlie, Inger ;

Mollnes, Tom Eirik .

IMMUNOBIOLOGY, 2015, 220 (04) :452-459

[5] Generation of C5a in the absence of C3: a new complement activation pathway [J].

Huber-Lang, Markus ;

Sarma, J. Vidya ;

Zetoune, Firas S. ;

Rittirsch, Daniel ;

Neff, Thomas A. ;

McGuire, Stephanie R. ;

Lambris, John D. ;

Warner, Roscoe L. ;

Flierl, Michael A. ;

Hoesel, Laszlo M. ;

Gebhard, Florian ;

Younger, John G. ;

Drouin, Scott M. ;

Wetsel, Rick A. ;

Ward, Peter A. .

NATURE MEDICINE, 2006, 12 (06) :682-687

[6] Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway [J].

Krisinger, Michael J. ;

Goebeler, Verena ;

Lu, Zhen ;

Meixner, Scott C. ;

Myles, Timothy ;

Pryzdial, Edward L. G. ;

Conway, Edward M. .

BLOOD, 2012, 120 (08) :1717-1725

[7] ACTIVATION OF THE 5TH COMPONENT OF HUMAN-COMPLEMENT, C5, WITHOUT CLEAVAGE, BY METHIONINE OXIDIZING-AGENTS [J].

VOGT, W ;

ZIMMERMANN, B ;

HESSE, D ;

NOLTE, R .

MOLECULAR IMMUNOLOGY, 1992, 29 (02) :251-256

[8] RADIOIMMUNOASSAY FOR ANAPHYLATOXINS - A SENSITIVE METHOD FOR DETERMINING COMPLEMENT ACTIVATION PRODUCTS IN BIOLOGICAL-FLUIDS [J].

WAGNER, JL ;

HUGLI, TE .

ANALYTICAL BIOCHEMISTRY, 1984, 136 (01) :75-88

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