Microwave-assisted synthesis and evaluation of anti-inflammatory activity of new series of N-substituted 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives

被引：22

作者：

Gaonkar, S. L. ^{[1
]}

Rai, K. M. Lokanatha ^{[1
]}

Shetty, N. Suchetha ^{[2
]}

机构：

[1] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India

[2] Justice KS Hegde Med Acad, Dept Biochem, Mangalore 574160, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2009年 / 18卷 / 03期

关键词：

Anti-inflammatory; Imidazole-carbaldehyde; Microwave irradiation; IMIDAZOLE; ANTIBACTERIAL; POTENT;

D O I：

10.1007/s00044-008-9121-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-substituted 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives bearing potentially bioactive substituents were synthesized by microwave irradiation method in good yield compared with conventional method. The synthesized compounds were screened for their anti-inflammatory activity and were compared with a standard drug. The compounds demonstrated potent to weak anti-inflammatory activity. Of the compounds studied, compounds 6i and 6d showed potent activity comparable to the standard drug ibuprofen at the same dose in carrageenan-induced paw edema in rat model.

引用

页码：221 / 230

页数：10

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