Toxic effects of magnesium oxide nanopartides on early developmental and larval stages of zebrafish (Danio rerio)

被引：61

作者：

Ghobadian, Mehdi ^{[1
]}

Nabiuni, Mohammad ^{[1
]}

Parivar, Kazem ^{[1
]}

Fathi, Mojtaba ^{[2
]}

Pazooki, Jamileh ^{[3
]}

机构：

[1] Kharazmi Univ, Fac Biol Sci, Dept Dev Biol, POB 15719-14911, Tehran, Iran

[2] Zanjan Univ Med Sci, Dept Biochem, Zanjan, Iran

[3] Shahid Beheshti Univ, Dept Biol Sci, Tehran, Iran

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2015年 / 122卷

关键词：

Zebrafish; Fish embryos; Toxicity; Malformation; MgO nanoparticles; ANTIBACTERIAL AGENT PREPARATION; SILVER NANOPARTICLES; MGO NANOPARTICLES; ENGINEERED NANOMATERIALS; TIO2; NANOPARTICLES; MUTATIONS; SURFACES; MGO(100); EMBRYOS; MODEL;

D O I：

10.1016/j.ecoenv.2015.08.009

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Magnesium oxide nanoparticles (MgONPs) are used in medicine, manufacturing and food industries. Because of their extensive application in our daily lives, environmental exposure to these nanoparticles is inevitable. The present study examined the effects of MgONPs on zebrafish (Danio rerio) early developmental stages. The results showed that, at different concentrations, MgONPs induced cellular apoptosis and intracellular reactive oxygen species. The hatching rate and survival of embryos decreased in a dose dependent manner. The 96-h LC50 value of MgONPs on zebrafish survival was 428 mg/l and the 48-h EC50 value of MgONPs on zebrafish embryo hatching rate was 175 mg/l. Moreover different types of malformation were observed in exposed embryos. The results demonstrate the toxic effects of MgONPs on zebrafish embryos and emphasize the need for further studies. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：260 / 267

页数：8

共 55 条

[1] Identification of 315 genes essential for early zebrafish development
Amsterdam, A
Nissen, RM
Sun, ZX
Swindell, EC
Farrington, S
Hopkins, N
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (35) : 12792 - 12797
[2] [Anonymous], 1996, ISO 7346
[3] Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles
Brown, DM
Donaldson, K
Borm, PJ
Schins, RP
Dehnhardt, M
Gilmour, P
Jimenez, LA
Stone, V
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2004, 286 (02) : L344 - L353
[4] Nanomaterials and nanoparticles: Sources and toxicity
Buzea, Cristina
Pacheco, Ivan I.
Robbie, Kevin
[J]. BIOINTERPHASES, 2007, 2 (04) : MR17 - MR71
[5] Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult zebrafish
Choi, Ji Eun
Kim, Soohee
Ahn, Jin Hee
Youn, Pilju
Kang, Jin Seok
Park, Kwangsik
Yi, Jongheop
Ryu, Doug-Young
[J]. AQUATIC TOXICOLOGY, 2010, 100 (02) : 151 - 159
[6] Toxicity assessment of TiO2 nanoparticles in zebrafish embryos under different exposure conditions
Clemente, Z.
Castro, V. L. S. S.
Moura, M. A. M.
Jonsson, C. M.
Fraceto, L. F.
[J]. AQUATIC TOXICOLOGY, 2014, 147 : 129 - 139
[7] The Complete Genome Sequence of the Plant Growth-Promoting Bacterium Pseudomonas sp UW4
Duan, Jin
Jiang, Wei
Cheng, Zhenyu
Heikkila, John J.
Glick, Bernard R.
[J]. PLOS ONE, 2013, 8 (03):
[8] Nano silver and nano zinc-oxide in surface waters - Exposure estimation for Europe at high spatial and temporal resolution
Dumont, Egon
Johnson, Andrew C.
Keller, Virginie D. J.
Williams, Richard J.
[J]. ENVIRONMENTAL POLLUTION, 2015, 196 : 341 - 349
[9] Zebrafish as a correlative and predictive model for assessing biomaterial nanotoxicity
Fako, Valerie E.
Furgeson, Darin Y.
[J]. ADVANCED DRUG DELIVERY REVIEWS, 2009, 61 (06) : 478 - 486
[10] Cytotoxic effects of MgO nanoparticles on human umbilical vein endothelial cells in vitro
Ge, S.
Wang, G.
Shen, Y.
Zhang, Q.
Jia, D.
Wang, H.
Dong, Q.
Yin, T.
[J]. IET NANOBIOTECHNOLOGY, 2011, 5 (02) : 36 - 40

← 1 2 3 4 5 6 →