Sonodynamic Therapy With Anticancer Micelles and High-Intensity Focused Ultrasound in Treatment of Canine Cancer

被引：35

作者：

Horise, Yuki ^{[1
]}

Maeda, Masanori ^{[2
]}

Konishi, Yoshiyuki ^{[1
]}

Okamoto, Jun ^{[1
]}

Ikuta, Soko ^{[1
]}

Okamoto, Yoshiharu ^{[3
]}

Ishii, Hiroshi ^{[4
]}

Yoshizawa, Shin ^{[5
]}

Umemura, Shinichiro ^{[6
]}

Ueyama, Tsuyoshi ^{[7
]}

Tamano, Satoshi ^{[8
]}

Sofuni, Atsushi ^{[9
]}

Takemae, Kazuhisa ^{[10
]}

Masamune, Ken ^{[1
]}

Iseki, Hiroshi ^{[1
]}

Nishiyama, Nobuhiro ^{[11
]}

Kataoka, Kazunori ^{[12
]}

Muragaki, Yoshihiro ^{[1
]}

机构：

[1] Tokyo Womens Med Univ, Inst Adv Biomed Engn & Sci, Tokyo, Japan

[2] MakeWay Merger Co, Saitama, Japan

[3] Tottori Univ, Fac Agr, Tottori, Japan

[4] Tokyo Anim Med Ctr, Tokyo, Japan

[5] Tohoku Univ, Dept Commun Engn, Sendai, Miyagi, Japan

[6] Tohoku Univ, Dept Biomed Engn, Sendai, Miyagi, Japan

[7] DENSO Corp, Med Business Dept, Nisshin, Japan

[8] Hitachi Ltd, Healthcare Business Unit, Tokyo, Japan

[9] Tokyo Med Univ Hosp, Dept Gastroenterol & Hepatol, Tokyo, Japan

[10] Kowa Co Ltd, Div Pharmaceut, Tokyo, Japan

[11] Tokyo Inst Technol, Div Polymer Chem, Tokyo, Japan

[12] Univ Tokyo, Dept Mat Engn, Tokyo, Japan

来源：

FRONTIERS IN PHARMACOLOGY | 2019年 / 10卷

基金：

日本科学技术振兴机构;

关键词：

sonodynamic therapy; minimally invasive; drug delivery system; high-intensity focused ultrasound; anticancer micelles; PHOTODYNAMIC THERAPY; LUNG-CANCER; PERMEABILITY; ENHANCEMENT; APOPTOSIS; SYSTEM; BREAST; SAFETY; TUMORS; DOGS;

D O I：

10.3389/fphar.2019.00545

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sonodynamic therapy (SDT) is a minimally invasive anticancer therapy involving a chemical sonosensitizer and high-intensity focused ultrasound (HIFU). SDT enables the reduction of drug dose and HIFU irradiation power compared to those of conventional monotherapies. In our previous study, mouse models of colon and pancreatic cancer were used to confirm the effectiveness of SDT vs. drug-only or HIFU-only therapy. To validate its usefulness, we performed a clinical trial of SDT using an anticancer micelle (NC-6300) and our HIFU system in four pet dogs with spontaneous tumors, including chondrosarcoma, osteosarcoma, hepatocellular cancer, and prostate cancer. The fact that no adverse events were observed, suggests the usefulness of SDT.

引用

页数：11

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