Sonodynamic Therapy With Anticancer Micelles and High-Intensity Focused Ultrasound in Treatment of Canine Cancer

被引：35

作者：

Horise, Yuki ^{[1
]}

Maeda, Masanori ^{[2
]}

Konishi, Yoshiyuki ^{[1
]}

Okamoto, Jun ^{[1
]}

Ikuta, Soko ^{[1
]}

Okamoto, Yoshiharu ^{[3
]}

Ishii, Hiroshi ^{[4
]}

Yoshizawa, Shin ^{[5
]}

Umemura, Shinichiro ^{[6
]}

Ueyama, Tsuyoshi ^{[7
]}

Tamano, Satoshi ^{[8
]}

Sofuni, Atsushi ^{[9
]}

Takemae, Kazuhisa ^{[10
]}

Masamune, Ken ^{[1
]}

Iseki, Hiroshi ^{[1
]}

Nishiyama, Nobuhiro ^{[11
]}

Kataoka, Kazunori ^{[12
]}

Muragaki, Yoshihiro ^{[1
]}

机构：

[1] Tokyo Womens Med Univ, Inst Adv Biomed Engn & Sci, Tokyo, Japan

[2] MakeWay Merger Co, Saitama, Japan

[3] Tottori Univ, Fac Agr, Tottori, Japan

[4] Tokyo Anim Med Ctr, Tokyo, Japan

[5] Tohoku Univ, Dept Commun Engn, Sendai, Miyagi, Japan

[6] Tohoku Univ, Dept Biomed Engn, Sendai, Miyagi, Japan

[7] DENSO Corp, Med Business Dept, Nisshin, Japan

[8] Hitachi Ltd, Healthcare Business Unit, Tokyo, Japan

[9] Tokyo Med Univ Hosp, Dept Gastroenterol & Hepatol, Tokyo, Japan

[10] Kowa Co Ltd, Div Pharmaceut, Tokyo, Japan

[11] Tokyo Inst Technol, Div Polymer Chem, Tokyo, Japan

[12] Univ Tokyo, Dept Mat Engn, Tokyo, Japan

来源：

FRONTIERS IN PHARMACOLOGY | 2019年 / 10卷

基金：

日本科学技术振兴机构;

关键词：

sonodynamic therapy; minimally invasive; drug delivery system; high-intensity focused ultrasound; anticancer micelles; PHOTODYNAMIC THERAPY; LUNG-CANCER; PERMEABILITY; ENHANCEMENT; APOPTOSIS; SYSTEM; BREAST; SAFETY; TUMORS; DOGS;

D O I：

10.3389/fphar.2019.00545

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sonodynamic therapy (SDT) is a minimally invasive anticancer therapy involving a chemical sonosensitizer and high-intensity focused ultrasound (HIFU). SDT enables the reduction of drug dose and HIFU irradiation power compared to those of conventional monotherapies. In our previous study, mouse models of colon and pancreatic cancer were used to confirm the effectiveness of SDT vs. drug-only or HIFU-only therapy. To validate its usefulness, we performed a clinical trial of SDT using an anticancer micelle (NC-6300) and our HIFU system in four pet dogs with spontaneous tumors, including chondrosarcoma, osteosarcoma, hepatocellular cancer, and prostate cancer. The fact that no adverse events were observed, suggests the usefulness of SDT.

引用

页数：11

共 50 条

[21] Robotic High-Intensity Focused Ultrasound (rHIFU) For the Prostate Cancer Treatment
Solovov, Vyacheslav
Shaplygin, Leonid
Vozdvizhenskiy, Mikhail
12TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND, 2012, 1503 : 305 - 310
[22] High-intensity focused ultrasound treatment for patients with unresectable pancreatic cancer
Peng-Zhou Li
Hepatobiliary & Pancreatic Diseases International, 2012, 11 (06) : 655 - 660
[23] High-intensity focused ultrasound therapy for the treatment of prostate cancer: Medium-term experience
Duran-Rivera, A.
Montoliu Garcia, A.
Juan Escudero, J.
Garrido Abad, P.
Fernandez Arjona, M.
Lopez Alcina, E.
ACTAS UROLOGICAS ESPANOLAS, 2018, 42 (07): : 450 - 456
[24] Noninvasive Treatment of Breast Cancer Using High-Intensity Focused Ultrasound
Zhou, Yufeng
JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS, 2013, 3 (02) : 141 - 156
[25] Parameter estimation in high-intensity focused ultrasound therapy
de los Rios Cardenas, Laura
Bermeo Varon, Leonardo A.
de Albuquerque Pereira, Wagner Coelho
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING, 2022, 38 (05)
[26] High-intensity focused ultrasound treatment for hepatocellular carcinoma
Sofuni, Atsushi
Takeuchi, Hirohito
Sugimoto, Katsutoshi
Itoi, Takao
Miyazawa, Hideaki
JOURNAL OF MEDICAL ULTRASONICS, 2024,
[27] High-intensity focused ultrasound ablation of breast cancer
Wu, Feng
ter Haar, Gail
Chen, Wei R.
EXPERT REVIEW OF ANTICANCER THERAPY, 2007, 7 (06) : 823 - 831
[28] High-intensity focused ultrasound for treating prostate cancer
Acher, Peter L.
Hodgson, Dominic J.
Murphy, Declan G.
Cahill, Declan J.
BJU INTERNATIONAL, 2007, 99 (01) : 28 - 32
[29] TREATMENT OF REFRACTORY GLAUCOMA WITH HIGH-INTENSITY FOCUSED ULTRASOUND
VALTOT, F
KOPEL, J
PETIT, E
MOULIN, F
HAUT, J
JOURNAL FRANCAIS D OPHTALMOLOGIE, 1995, 18 (01): : 3 - 12
[30] Treatment of liver alveococcosis with high-intensity focused ultrasound
Imankulov, S. B.
Fedotovskikh, G. V.
Zhampeissov, N. K.
Yerlan, M.
Shaimardanova, G. M.
Knaub, L. V.
ULTRASONICS SONOCHEMISTRY, 2015, 27 : 707 - 711

← 1 2 3 4 5 →