Sonodynamic Therapy With Anticancer Micelles and High-Intensity Focused Ultrasound in Treatment of Canine Cancer

被引：35

作者：

Horise, Yuki ^{[1
]}

Maeda, Masanori ^{[2
]}

Konishi, Yoshiyuki ^{[1
]}

Okamoto, Jun ^{[1
]}

Ikuta, Soko ^{[1
]}

Okamoto, Yoshiharu ^{[3
]}

Ishii, Hiroshi ^{[4
]}

Yoshizawa, Shin ^{[5
]}

Umemura, Shinichiro ^{[6
]}

Ueyama, Tsuyoshi ^{[7
]}

Tamano, Satoshi ^{[8
]}

Sofuni, Atsushi ^{[9
]}

Takemae, Kazuhisa ^{[10
]}

Masamune, Ken ^{[1
]}

Iseki, Hiroshi ^{[1
]}

Nishiyama, Nobuhiro ^{[11
]}

Kataoka, Kazunori ^{[12
]}

Muragaki, Yoshihiro ^{[1
]}

机构：

[1] Tokyo Womens Med Univ, Inst Adv Biomed Engn & Sci, Tokyo, Japan

[2] MakeWay Merger Co, Saitama, Japan

[3] Tottori Univ, Fac Agr, Tottori, Japan

[4] Tokyo Anim Med Ctr, Tokyo, Japan

[5] Tohoku Univ, Dept Commun Engn, Sendai, Miyagi, Japan

[6] Tohoku Univ, Dept Biomed Engn, Sendai, Miyagi, Japan

[7] DENSO Corp, Med Business Dept, Nisshin, Japan

[8] Hitachi Ltd, Healthcare Business Unit, Tokyo, Japan

[9] Tokyo Med Univ Hosp, Dept Gastroenterol & Hepatol, Tokyo, Japan

[10] Kowa Co Ltd, Div Pharmaceut, Tokyo, Japan

[11] Tokyo Inst Technol, Div Polymer Chem, Tokyo, Japan

[12] Univ Tokyo, Dept Mat Engn, Tokyo, Japan

来源：

FRONTIERS IN PHARMACOLOGY | 2019年 / 10卷

基金：

日本科学技术振兴机构;

关键词：

sonodynamic therapy; minimally invasive; drug delivery system; high-intensity focused ultrasound; anticancer micelles; PHOTODYNAMIC THERAPY; LUNG-CANCER; PERMEABILITY; ENHANCEMENT; APOPTOSIS; SYSTEM; BREAST; SAFETY; TUMORS; DOGS;

D O I：

10.3389/fphar.2019.00545

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sonodynamic therapy (SDT) is a minimally invasive anticancer therapy involving a chemical sonosensitizer and high-intensity focused ultrasound (HIFU). SDT enables the reduction of drug dose and HIFU irradiation power compared to those of conventional monotherapies. In our previous study, mouse models of colon and pancreatic cancer were used to confirm the effectiveness of SDT vs. drug-only or HIFU-only therapy. To validate its usefulness, we performed a clinical trial of SDT using an anticancer micelle (NC-6300) and our HIFU system in four pet dogs with spontaneous tumors, including chondrosarcoma, osteosarcoma, hepatocellular cancer, and prostate cancer. The fact that no adverse events were observed, suggests the usefulness of SDT.

引用

页数：11

共 50 条

[1] High-intensity focused ultrasound therapy for prostate cancer
Uchida, Toyoaki
Nakano, Mayura
Hongo, Satoko
Shoji, Sunao
Nagata, Yohishiro
Satoh, Takefumi
Baba, Shiro
Usui, Yukio
Terachi, Toshiro
INTERNATIONAL JOURNAL OF UROLOGY, 2012, 19 (03) : 187 - 201
[2] High-intensity focused ultrasound therapy
Cheung, Vincent Y. T.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2018, 46 : 74 - 83
[3] Versatile nanocomposite augments high-intensity focused ultrasound for high-efficacy sonodynamic therapy of glioma
Zheng, Yingyan
She, Dejun
Huang, Huihui
Lin, Lin
Chen, Sunhui
Lu, Yiping
Liu, Li
Pang, Zhiqing
Yin, Bo
NANO RESEARCH, 2022, 15 (10) : 9082 - 9091
[4] Versatile nanocomposite augments high-intensity focused ultrasound for high-efficacy sonodynamic therapy of glioma
Yingyan Zheng
Dejun She
Huihui Huang
Lin Lin
Sunhui Chen
Yiping Lu
Li Liu
Zhiqing Pang
Bo Yin
Nano Research, 2022, 15 : 9082 - 9091
[5] High-intensity focused ultrasound therapy for pancreatic cancer
Sofuni, Atsushi
Asai, Yasutsugu
Mukai, Shuntaro
Yamamoto, Kenjiro
Itoi, Takao
JOURNAL OF MEDICAL ULTRASONICS, 2022,
[6] High-Intensity Focused Ultrasound in the Treatment of Breast Cancer
Feril, Loreto B., Jr.
Fernan, Rodney L.
Tachibana, Katsuro
CURRENT MEDICINAL CHEMISTRY, 2021, 28 (25) : 5179 - 5188
[7] pH-Responsive Nanoparticles for Enhanced Antitumor Activity by High-Intensity Focused Ultrasound Therapy Combined with Sonodynamic Therapy
Gao, Hui
Wang, Zhaoxia
Tan, Mixiao
Liu, Weiwei
Zhang, Liang
Huang, Ju
Cao, Yang
Li, Pan
Wang, Zhigang
Wen, Jiexin
Shang, Tingting
Ran, Haitao
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2022, 17 : 333 - 350
[8] Clinical Application of High-intensity Focused Ultrasound in Cancer Therapy
Hsiao, Yi-Hsuan
Kuo, Shou-Jen
Tsai, Horng-Der
Chou, Ming-Chih
Yeh, Guang-Perng
JOURNAL OF CANCER, 2016, 7 (03): : 225 - 231
[9] High-Intensity Focused Ultrasound Treatment for Advanced Pancreatic Cancer
Zhou, Yufeng
GASTROENTEROLOGY RESEARCH AND PRACTICE, 2014, 2014
[10] Safety trial of high-intensity focused ultrasound therapy for pancreatic cancer
Atsushi Sofuni
Fuminori Moriyasu
Takatomo Sano
Fumihide Itokawa
Takayoshi Tsuchiya
Toshio Kurihara
Kentaro Ishii
Syujiro Tsuji
Nobuhito Ikeuchi
Reina Tanaka
Junko Umeda
Ryosuke Tonozuka
Mitsuyoshi Honjo
Shuntaro Mukai
Mitsuru Fujita
Takao Itoi
World Journal of Gastroenterology, 2014, (28) : 9570 - 9577

← 1 2 3 4 5 →