Oxidants painting the cysteine chapel: Redox regulation of PTPs

被引：128
|
作者：
Xu, D [1 ]
Rovira, II [1 ]
Finkel, T [1 ]
机构：
[1] NHLBI, Cardiovasc Branch, NIH, Bethesda, MD 20892 USA
来源：
DEVELOPMENTAL CELL | 2002年 / 2卷 / 03期
关键词：
D O I：
10.1016/S1534-5807(02)00132-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Growth factors and cytokines appear to stimulate the intracellular production of reactive oxygen species (ROS). Evidence suggests that this alteration in the cellular redox state is essential for downstream signaling, but the precise mechanism has remained elusive. A new study now demonstrates that ligand-stimulated intracellular hydrogen peroxide can specifically and reversibly regulate the activity of protein tyrosine phosphatases.
引用
收藏
页码：251 / 252
页数：2
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