Ascorbic Acid in Postoperative Intensive Care Patients - Biochemical Aspects and Clinical Experience

被引：0

作者：

Ruemelin, Andreas ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Dept Anesthesiol, Mainz, Germany

来源：

CURRENT MEDICINAL CHEMISTRY | 2009年 / 16卷 / 02期

关键词：

Vitamin C; ascorbic acid; intensive care; ICU; metabolism; trauma; operation; VASCULAR ENDOTHELIAL-CELLS; OXIDE SYNTHASE EXPRESSION; VITAMIN-C; OXIDATIVE STRESS; NITRIC-OXIDE; ISCHEMIA-REPERFUSION; DEHYDROASCORBIC ACID; LIPID-PEROXIDATION; HUMAN ERYTHROCYTES; IN-VIVO;

D O I：

10.2174/092986709787002781

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transport mechanisms of ascorbic acid (AA) are described. The metabolism of AA and its function as an antioxidant are covered in some detail. Subsequently, indications for postoperative substitution are discussed. The supplementation of up to 300 mg of AA per day in postoperative intensive care unit patients during par-/enteral nutrition is recommended to prevent hypovitaminosis. It is not clear if this is the optimal dosage of AA in postoperative/-trauma patients. New aspects for an AA substitution are discussed.

引用

页码：184 / 188

页数：5

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