Synthesis of Unnatural Small Molecules by Plant Specific Polyketide Synthases

被引：2

作者：

Zhang, Le ^{[1
]}

Wang, Juan ^{[1
]}

Li, Bin ^{[1
]}

Gao, Bowen ^{[1
]}

Wang, Xiaohui ^{[1
]}

Shi, Shepo ^{[1
]}

Tu, Pengfei ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 33卷 / 12期

关键词：

plant polyketide synthases; unnatural small molecules; combinatorial synthesis; combinatorial biosynthesis; CHAIN-LENGTH CONTROL; CHALCONE SYNTHASE; COMBINATORIAL BIOSYNTHESIS; ACTIVE-SITE; SUBSTRATE-SPECIFICITY; BENZOPHENONE SYNTHASE; ENZYMATIC FORMATION; ESCHERICHIA-COLI; CELL-CULTURES; STILBENE;

D O I：

10.6023/cjoc201307012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Plant polyketide synthases (PKSs) catalyze iterative decarboxylative condensations of malonyl units (Claisen-type C-C bond formation) with a CoA-linked starter molecule to produce linear chain polyketide intermediates. By Claisen, aldol cyclization, or lactonization, and aromatization, the linear chain polyketide intermediates produce varied unnatural small molecules. In this review, the functions of the known plant PKSs are summarized, and the catalytic mechanisms and applications of plant PKSs in the synthesis of unnatural small molecules are covered.

引用

页码：2469 / 2484

页数：16

共 77 条

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