Differential effects of charybdotoxin on the activity of retinal ganglion cells in the dark- and light-adapted mouse retina

被引：10

作者：

Nemargut, Joseph P. ^{[1
]}

Zhu, Junling ^{[1
]}

Savoie, Brian T. ^{[1
]}

Wang, Guo-Yong ^{[1
]}

机构：

[1] Tulane Univ, Sch Med, Dept Struct & Cellular Biol, New Orleans, LA 70112 USA

来源：

VISION RESEARCH | 2009年 / 49卷 / 03期

关键词：

Calcium-activated potassium channels; Retinal ganglion cells; Dark adaptation; Light adaptation; BK channels; ACTIVATED POTASSIUM CHANNELS; AMACRINE CELLS; CONE PHOTORECEPTORS; MAMMALIAN RETINA; EVOKED RESPONSES; NEURONS INVITRO; INNER SEGMENT; BIPOLAR CELLS; ROD PATHWAYS; CONDUCTANCES;

D O I：

10.1016/j.visres.2008.11.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Patch-clamp recordings were made from retinal ganglion cells in the mouse retina. Under dark adaptation, blockage of BKca, channels increases the spontaneous excitatory postsynaptic currents (EPSCs) and light-evoked On-EPSCs, while it decreases the light-evoked Off inhibitory postsynaptic currents (IPSCs). However, under light adaptation it decreases the light-evoked On-EPSCs, the spontaneous IPSCs and the light-evoked On- and Off-IPSCs. Blockage of BKca channels significantly altered the outputs of RGCs by changing their light-evoked responses into a bursting pattern and increasing the light-evoked depolarization of the membrane potentials, while it did not significantly change the peak firing rates of light-evoked responses. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：388 / 397

页数：10

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