Graphene oxide/hydroxyapatite composite coatings fabricated by electrophoretic nanotechnology for biological applications

被引：258
作者：
Li, Ming [1 ]
Liu, Qian [1 ]
Jia, Zhaojun [1 ]
Xu, Xuchen [1 ]
Cheng, Yan [1 ]
Zheng, Yufeng [1 ,2 ]
Xi, Tingfei [1 ]
Wei, Shicheng [1 ,3 ]
机构：
[1] Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
[2] Peking Univ, Coll Engn, Dept Mat Sci & Engn, Beijing 100871, Peoples R China
[3] Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
来源：
CARBON | 2014年 / 67卷
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
TITANIUM SUBSTRATE; GRAPHITE OXIDE; MECHANICAL-PROPERTIES; IN-VITRO; HYDROXYAPATITE; DEPOSITION; NANOCOMPOSITES; LAYER; BIOCOMPATIBILITY; CELLS;
D O I：
10.1016/j.carbon.2013.09.080
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Graphene oxide (GO) was firstly employed as nanoscale reinforcement fillers in hydroxyapatite (HA) coatings by a cathodic electrophoretic deposition process, and GO/HA coatings were fabricated on pure Ti substrate. The transmission electron microscopy observation and particle size analysis of the suspensions indicated that HA nanoparticles were uniformly decorated on GO sheets, forming a large GO/HA particle group. The addition of GO into HA coatings could reduce the surface cracks and increase the coating adhesion strength from 1.55 +/- 0.39 MPa (pure HA) to 2.75 +/- 0.38 MPa (2 wt.% GO/HA) and 3.3 +/- 0.25 MPa (5 wt.% GO/HA), respectively. Potentiodynamic polarization and electrochemical impedance spectroscopy studies indicated that the GO/HA composite coatings exhibited higher corrosion resistance in comparison with pure HA coatings in simulated body fluid. In addition, superior (around 95% cell viability for 2 wt.% GO/HA) or comparable (80-90% cell viability for 5 wt.% GO/HA) in vitro biocompatibility were observed in comparison with HA coated and uncoated Ti substrate. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：185 / 197
页数：13
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