Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists

被引：11

作者：

Sato, N ^{[1
]}

Shibata, T ^{[1
]}

Jitsuoka, M ^{[1
]}

Ohno, T ^{[1
]}

Takahashi, T ^{[1
]}

Hirohashi, T ^{[1
]}

Kanno, T ^{[1
]}

Iwaasa, H ^{[1
]}

Kanatani, A ^{[1
]}

Fukami, T ^{[1
]}

机构：

[1] Banyu Pharmaceut Co Ltd, Tsukuba Res Inst, Tsukuba, Ibaraki 3002611, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 07期

关键词：

D O I：

10.1016/j.bmcl.2004.01.049

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of substituted 4-alkoxy-2-aminopyridines 2, which were formally derived from neuropeptide Y1 antagonist 1 by replacing the morpholino portion with alkoxy groups, were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists. Primary structure-activity relationships and identification of potent 4-alkoxy derivatives are described. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1761 / 1764

页数：4

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