Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists

被引：11
|
作者：
Sato, N [1 ]
Shibata, T [1 ]
Jitsuoka, M [1 ]
Ohno, T [1 ]
Takahashi, T [1 ]
Hirohashi, T [1 ]
Kanno, T [1 ]
Iwaasa, H [1 ]
Kanatani, A [1 ]
Fukami, T [1 ]
机构：
[1] Banyu Pharmaceut Co Ltd, Tsukuba Res Inst, Tsukuba, Ibaraki 3002611, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 07期
关键词：
D O I：
10.1016/j.bmcl.2004.01.049
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of substituted 4-alkoxy-2-aminopyridines 2, which were formally derived from neuropeptide Y1 antagonist 1 by replacing the morpholino portion with alkoxy groups, were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists. Primary structure-activity relationships and identification of potent 4-alkoxy derivatives are described. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1761 / 1764
页数：4
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