Recent progress in nanomedicine: therapeutic, diagnostic and theranostic applications

被引：243

作者：

Rizzo, Larissa Y. ^{[1
]}

Theek, Benjamin ^{[1
]}

Storm, Gert ^{[2
,3
]}

Kiessling, Fabian ^{[1
]}

Lammers, Twan ^{[1
,2
,3
]}

机构：

[1] Rhein Westfal TH Aachen, Univ Clin & Helmholtz Inst Biomed Engn, Dept Expt Mol Imaging, Aachen, Germany

[2] Univ Twente, MIRA Inst Biomed Technol & Tech Med, Dept Targeted Therapeut, NL-7500 AE Enschede, Netherlands

[3] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Utrecht, Netherlands

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2013年 / 24卷 / 06期

基金：

欧洲研究理事会;

关键词：

MAGNETIC-RESONANCE; PERSONALIZED NANOMEDICINE; SOLID TUMORS; CANCER; NANOPARTICLES; ACCUMULATION; TRACKING; DELIVERY; NANOTHERANOSTICS; MICROBUBBLES;

D O I：

10.1016/j.copbio.2013.02.020

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, the use of nanomedicine formulations for therapeutic and diagnostic applications has increased exponentially. Many different systems and strategies have been developed for drug targeting to pathological sites, as well as for visualizing and quantifying important (patho-) physiological processes. In addition, ever more efforts have been undertaken to combine diagnostic and therapeutic properties within a single nanomedicine formulation. These socalled nanotheranostics are able to provide valuable information on drug delivery, drug release and drug efficacy, and they are considered to be highly useful for personalizing nanomedicine-based (chemo-) therapeutic interventions.

引用

页码：1159 / 1166

页数：8

共 52 条

[1] Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging [J].