Continuing war on pain: a personalized approach to the therapy with nonsteroidal anti-inflammatory drugs and opioids

被引：13

作者：

Bach-Rojecky, Lidija ^{[1
]}

Vadunec, Dalia ^{[1
]}

Zunic, Katarina ^{[1
]}

Kurija, Jelena ^{[1
]}

Sipicki, Sara ^{[1
]}

Gregg, Ryan ^{[2
]}

Mikula, Ivan ^{[3
,4
,5
]}

Primorac, Dragan ^{[3
,4
,5
,6
,7
,8
,9
,10
,11
]}

机构：

[1] Univ Zagreb, Dept Pharmacol, Fac Pharm & Biochem, A Kovacica 1, Zagreb 10000, Croatia

[2] OneOme LLC, 807 Broadway St NE 100, Minneapolis, MN 55413 USA

[3] St Catherine Specialty Hosp, Zagreb 10000, Croatia

[4] St Catherine Specialty Hosp, Zagreb 10000, Croatia

[5] St Catherine Specialty Hosp, Zabok 49210, Croatia

[6] Penn State Univ, Eberly Coll Sci, Dept Forens Sci, 517 Thomas St, State Coll, PA 16803 USA

[7] Univ Split, Dept Pediat, Sch Med, Soltanska 2, Split 21000, Croatia

[8] Univ Osijek, Dept Pediat, Sch Med, Ul Cara Hadrijana 10, Osijek 31000, Croatia

[9] Univ Osijek, Fac Dent Med & Hlth, Dept Pediat, Crkvena 21, Osijek 31000, Croatia

[10] Univ Rijeka, Sch Med, Dept Biotechnol, Brce Branchetta 20-1, Rijeka 51000, Croatia

[11] Childrens Hosp Srebrnjak, Srebrnjak 100, Zagreb 10000, Croatia

来源：

PERSONALIZED MEDICINE | 2019年 / 16卷 / 02期

关键词：

analgesic effect; epigenetics; genes; nonsteroidal anti-inflammatory drugs; opioids; pain treatment; pharmacogenetics; side effects; toxicity; CLINICAL PHARMACOKINETICS; INDIVIDUAL-DIFFERENCES; EPIGENETIC REGULATION; MORPHINE; METABOLISM; PHARMACOGENETICS; BIOAVAILABILITY; PHARMACOLOGY; POLYMORPHISM; CYP2C9;

D O I：

10.2217/pme-2018-0116

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Successful pain management requires the delivery of analgesia with minimal risk of adverse drug reactions. Nonsteroidal anti-inflammatory drugs and opioids remain the mainstay of treatment for the majority of patients. Unfortunately, almost 50% of all patients experience inadequate pain relief and serious side effects. Allelic variants in genes coding for target proteins, transporters and enzymes, which govern analgesic drugs action and their fate in the organism, might explain inter-individual variability in pain severity and in drug-induced pain relief and toxicities. Additionally, it seems that epigenetic changes contribute to the highly variable response to pain treatment. Therefore, pharmacogenomic testing might be a valuable tool for personalization of pain treatment, with a multidisciplinary team approach involved.

引用

页码：171 / 184

页数：14

共 89 条

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