Reduction-Controlled Release of Organic Nanoparticles from Disulfide Cross-linked Porous Polymer

被引：8

作者：

Grant, Neil ^{[1
]}

Wu, Hong ^{[2
]}

Zhang, Haifei ^{[1
]}

机构：

[1] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

[2] Fourth Mil Med Univ, Sch Pharm, Dept Pharmaceut Chem & Pharmaceut Anal, Xian 710032, Peoples R China

来源：

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH | 2014年 / 53卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

DRUG-DELIVERY CARRIERS; IN-VITRO RELEASE; HYDROGELS; MICELLES; TRIS(2-CARBOXYETHYL)PHOSPHINE; DITHIOTHREITOL; DOXORUBICIN; COPOLYMERS; CAPSULES; NANOGELS;

D O I：

10.1021/ie403001r

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Reduction-controlled release is favored for many applications. The cleavage of disulfide bonds is known to be sensitive to reducing agents. Here, a cross-linker containing a disulfide bond is prepared and then used to prepare cross-linked porous polymer via an emulsion templating approach. Oil-in-water (O/W) emulsions are first formed where an organic dye is dissolved in the oil droplet phase and monomer/cross-linker/surfactant are added into the continuous aqueous phase. By polymerizing the O/W emulsion followed by freeze-drying, organic nanoparticles are formed in situ within the disulfide-crosslinked porous polymer. The release of organic nanoparticles in water is demonstrated and can be tuned by the presence of reducing agents such as dithiothreitol and tris(2-carboxyethyl)phospine. This approach has the potential to be used for the reduction-controlled release of poorly water-soluble drug nanoparticles from porous polymers or hydrogels.

引用

页码：246 / 252

页数：7

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