Palladacycle-Catalyzed Deacetonative Sonogashira Coupling of Aryl Propargyl Alcohols with Aryl Chlorides

被引：52
|
作者：
Hu, Hao [1 ]
Yang, Fan [1 ]
Wu, Yangjie [1 ]
机构：
[1] Zhengzhou Univ, Coll Chem & Mol Engn, Henan Key Lab Chem Biol & Organ Chem, Key Lab Appl Chem Henan Univ, Zhengzhou 450052, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 20期
基金：
中国国家自然科学基金;
关键词：
ALKYNYL CARBOXYLIC-ACIDS; ONE-POT SYNTHESIS; TERMINAL ALKYNES; PALLADIUM; EFFICIENT; DIARYLALKYNES; HALIDES; CARBON;
D O I：
10.1021/jo4014657
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and general protocol for the deacetonative Sonogashira coupling of aryl propargyl alcohols with aryl chlorides is described. The reaction proceeded smoothly with the catalyst system of palladacycle/Xphos. This result represents the first successful deacetonative Sonogashira version for electron-poor, electron-neutral, and even inactive sterically hindered electron-rich aryl chlorides.
引用
收藏
页码：10506 / 10511
页数：6
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