Palladacycle-Catalyzed Deacetonative Sonogashira Coupling of Aryl Propargyl Alcohols with Aryl Chlorides

被引：52

作者：

Hu, Hao ^{[1
]}

Yang, Fan ^{[1
]}

Wu, Yangjie ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem & Mol Engn, Henan Key Lab Chem Biol & Organ Chem, Key Lab Appl Chem Henan Univ, Zhengzhou 450052, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 20期

基金：

中国国家自然科学基金;

关键词：

ALKYNYL CARBOXYLIC-ACIDS; ONE-POT SYNTHESIS; TERMINAL ALKYNES; PALLADIUM; EFFICIENT; DIARYLALKYNES; HALIDES; CARBON;

D O I：

10.1021/jo4014657

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and general protocol for the deacetonative Sonogashira coupling of aryl propargyl alcohols with aryl chlorides is described. The reaction proceeded smoothly with the catalyst system of palladacycle/Xphos. This result represents the first successful deacetonative Sonogashira version for electron-poor, electron-neutral, and even inactive sterically hindered electron-rich aryl chlorides.

引用

页码：10506 / 10511

页数：6

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