Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging

被引：31

作者：

Tha, Khin K. ^{[1
]}

Terae, Satoshi ^{[2
]}

Nakagawa, Shin ^{[3
]}

Inoue, Takeshi ^{[3
]}

Kitagawa, Nobuki ^{[3
]}

Kako, Yuki ^{[3
]}

Nakato, Yasuya ^{[3
]}

Popy, Kawser Akter ^{[2
]}

Fujima, Noriyuki ^{[2
]}

Zaitsu, Yuri ^{[2
]}

Yoshida, Daisuke ^{[2
]}

Ito, Yoichi M. ^{[4
]}

Miyamoto, Tamaki ^{[5
]}

Koyama, Tsukasa ^{[3
]}

Shirato, Hiroki ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Radiobiol & Med Engn, Kita Ku, Sapporo, Hokkaido 0608638, Japan

[2] Hokkaido Univ, Grad Sch Med, Dept Diagnost Radiol, Kita Ku, Sapporo, Hokkaido 0608638, Japan

[3] Hokkaido Univ, Grad Sch Med, Dept Psychiat, Kita Ku, Sapporo, Hokkaido 0608638, Japan

[4] Hokkaido Univ, Grad Sch Med, Dept Biostat, Kita Ku, Sapporo, Hokkaido 0608638, Japan

[5] Hokkaido Univ, Grad Sch Med, Dept Hlth Sci, Kita Ku, Sapporo, Hokkaido 0608638, Japan

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2013年 / 212卷 / 03期

关键词：

Fractional anisotropy; Mean diffusivity; Voxel-based analysis; Histogram; WHITE-MATTER ABNORMALITIES; LATE-LIFE DEPRESSION; DORSOLATERAL PREFRONTAL CORTEX; CEREBRAL-BLOOD-FLOW; MICROSTRUCTURAL ABNORMALITIES; CEREBELLUM; ANISOTROPY; HISTOGRAM; SCHIZOPHRENIA; INTERVIEW;

D O I：

10.1016/j.pscychresns.2012.07.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Diffusion tensor imaging (DTI) is considered to be able to non-invasively quantify white matter integrity. This study aimed to use DTI to evaluate white matter integrity in non-geriatric patients with major depressive disorder (MDD) who were free of antidepressant medication. DTI was performed on 19 non-geriatric patients with MDD, free of antidepressant medication, and 19 age-matched healthy subjects. Voxel-based and histogram analyses were used to compare fractional anisotropy (FA) and mean diffusivity (MD) values between the two groups, using two-sample t tests. The abnormal DTI indices, if any, were tested for correlation with disease duration and severity, using Pearson product-moment correlation analysis. Voxel-based analysis showed clusters with FA decrease at the bilateral frontal white matter, anterior limbs of internal capsule, cerebellum, left putamen and right thalamus of the patients. Histogram analysis revealed lower peak position of FA histograms in the patients. FA values of the abnormal clusters and peak positions of FA histograms of the patients exhibited moderate correlation with disease duration and severity. These results suggest the implication of frontal-subcortical circuits and cerebellum in MDD, and the potential utility of FA in evaluation of brain parenchymal integrity. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：208 / 215

页数：8

共 60 条

[1] Microstructural white matter abnormalities and remission of geriatric depression [J].

Alexopoulos, George S. ;

Murphy, Christopher F. ;

Gunning-Dixon, Faith M. ;

Latoussakis, Vassilios ;

Kanellopoulos, Dora ;

Klimstra, Sibel ;

Lim, Kelvin O. ;

Hoptman, Matthew J. .

AMERICAN JOURNAL OF PSYCHIATRY, 2008, 165 (02) :238-244

[2] Frontal white matter microstructure and treatment response of late-life depression: A preliminary study [J].

Alexopoulos, GS ;

Kiosses, DN ;

Choi, SJ ;

Murphy, CF ;

Lim, KO .

AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (11) :1929-1932

[3] Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression [J].

Bae, Jae Nam ;

MacFall, James R. ;

Krishnan, K. Ranga R. ;

Payne, Martha E. ;

Steffens, David C. ;

Taylor, Warren D. .

BIOLOGICAL PSYCHIATRY, 2006, 60 (12) :1356-1363

[4] Quantification of Brain Maturation and Growth Patterns in C57BL/6J Mice via Computational Neuroanatomy of Diffusion Tensor Images [J].

Baloch, Sajjad ;

Verma, Ragini ;

Huang, Hao ;

Khurd, Parmeshwar ;

Clark, Sarah ;

Yarowsky, Paul ;

Abel, Ted ;

Mori, Susumu ;

Davatzikos, Christos .

CEREBRAL CORTEX, 2009, 19 (03) :675-687

[5]

Basser PJ, 1996, J MAGN RESON SER B, V111, P209, DOI [10.1006/jmrb.1996.0086, 10.1016/j.jmr.2011.09.022]

[6]

Beaulieu C., 2011, Diffusion MRI: Theory, Methods, and Applications, P92, DOI DOI 10.1093/MED/9780195369779.003.0007

[7] The functional neuroanatomy of major depression: an fMRI study using an emotional activation paradigm [J].

Beauregard, M ;

Leroux, JM ;

Bergman, S ;

Arzoumanian, Y ;

Beaudoin, G ;

Bourgouin, P ;

Stip, E .

NEUROREPORT, 1998, 9 (14) :3253-3258

[8] Microstructural Abnormalities in Subcortical Reward Circuitry of Subjects with Major Depressive Disorder [J].

Blood, Anne J. ;

Iosifescu, Dan V. ;

Makris, Nikos ;

Perlis, Roy H. ;

Kennedy, David N. ;

Dougherty, Darin D. ;

Kim, Byoung Woo ;

Lee, Myung Joo ;

Wu, Shirley ;

Lee, Sang ;

Calhoun, Jesse ;

Hodge, Steven M. ;

Fava, Maurizio ;

Rosen, Bruce R. ;

Smoller, Jordan W. ;

Gasic, Gregory P. ;

Breiter, Hans C. .

PLOS ONE, 2010, 5 (11)

[9]

Cercignani M, 2001, AM J NEURORADIOL, V22, P952

[10]

Cercignani M., 2011, Diffusion MRI : theory, methods, and application, P485

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