Photoredox-Catalyzed Trifluoromethylative Intramolecular Cyclization: Synthesis of CF3-Containing Heterocyclic Compounds

被引：30

作者：

Han, Hong Sik ^{[1
,2
]}

Oh, Eun Hye ^{[2
,3
]}

Jung, Young-Sik ^{[1
,2
]}

Han, Soo Bong ^{[1
,2
]}

机构：

[1] Univ Sci & Technol, Dept Med & Pharmaceut Chem, 217 Gajeongro, Yuseong 34113, Daejeon, South Korea

[2] Korea Res Inst Chem Technol, Div Bio & Drug Discovery, 141 Gajeongro, Yuseong 34114, Daejeon, South Korea

[3] Korea Univ, Dept Chem, 145 Anam Ro, Seoul 02841, South Korea

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 07期

关键词：

ASYMMETRIC HYDROGENATION; FACILE ACCESS; LIGHT; DERIVATIVES; ALKYNES; DESIGN; HETEROARENES; CONSTRUCT; FLUORINE;

D O I：

10.1021/acs.orglett.8b00648

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general photoredox-catalyzed intramolecular cyclization was developed for the synthesis of trifluoromethylated heterocydic compounds. The reaction proceeded smoothly under mild photocatalytic conditions with high functional group tolerance, allowing the preparation of oxygen-, sulfur-, or nitrogen-containing heterocycles of different sizes. The broad.,substrate scope demonstrated the complexity-building potential of the strategy.

引用

页码：1698 / 1702

页数：5

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