Beneficial effects of pioglitazone on cognitive impairment in MPTP model of Parkinson's disease

被引：87

作者：

Kumar, Pramod ^{[1
]}

Kaundal, Ravinder K. ^{[1
]}

More, Sandeep ^{[1
]}

Sharma, Shyam S. ^{[1
]}

机构：

[1] NIPER, Mol Neuropharmacol Lab, Dept Pharmacol & Toxicol, Mohali 160062, Punjab, India

来源：

BEHAVIOURAL BRAIN RESEARCH | 2009年 / 197卷 / 02期

关键词：

Cognition; Parkinson's disease; Dementia; Pioglitazone; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Oxidative stress; Substantia nigra pars compacta; NIGRA PARS COMPACTA; GAMMA AGONIST PIOGLITAZONE; ACTIVATED-RECEPTOR-GAMMA; NF-KAPPA-B; SUBSTANTIA-NIGRA; DOPAMINERGIC-NEURONS; ALZHEIMERS-DISEASE; MEMORY IMPAIRMENT; LESIONED RATS; MOUSE MODEL;

D O I：

10.1016/j.bbr.2008.10.010

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The present study was carried out to elucidate the beneficial effect of pioglitazone in cognitive impairment induced by bilateral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in substantia nigra pars compacta (SNc) in rats, a model of Parkinson's disease. MPTP-lesioned rats showed poor cognitive performance in both passive avoidance task and cued version of the Morris water maze test. This deficit in learning and memory was found to be associated with oxidative stress. Chronic administration of pioglitazone (10 and 30 mg/kg, p.o., starting 5 days prior to MPTP administration and then for next 30 days) in MPTP-lesioned rats improved cognitive performance in passive avoidance task and cued version of the Morris water maze test. Furthermore, pioglitazone treatment also reduced oxidative stress (as evident by reduced malondialdehyde and increased glutathione levels). These results demonstrate the beneficial effects of pioglitazone on cognitive impairment in MPTP induced Parkinson's disease in rats. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：398 / 403

页数：6

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