The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes

被引：112
|
作者：
Alvarez-Venegas, R
Sadder, M
Hlavacka, A
Baluska, F
Xia, YN
Lu, GQ
Firsov, A
Sarath, G
Moriyama, H
Dubrovsky, JG
Avramova, Z [1 ]
机构：
[1] Univ Nebraska, Sch Biol Sci, Lincoln, NE 68588 USA
[2] Univ Bonn, Inst Bot, Dept Plant Cell Biol, D-53115 Bonn, Germany
[3] Univ Nebraska, Ctr Biotechnol, Genom Core Res Facil, Lincoln, NE 68588 USA
[4] Univ Nebraska, Ctr Biotechnol, Bioinformat Core Res Facil, Lincoln, NE 68588 USA
[5] Univ Nebraska, USDA, Agr Res Serv Unit, Lincoln, NE 68583 USA
[6] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA
[7] Univ Nacl Autonoma Mexico, Inst Biotecnol, Cuernavaca 62250, Morelos, Mexico
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 15期
关键词：
epigenetic regulation; lipid signaling;
D O I：
10.1073/pnas.0600944103
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The Arabidopsis homolog of trithorax, ATX1, regulates numerous functions in Arabidopsis beyond the homeotic genes. Here, we identified genome-wide targets of ATX1 and showed that ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P. PI5P negatively affects ATX1 activity, suggesting a regulatory pathway connecting lipid-signaling with nuclear functions. We propose a model to illustrate how plants may respond to stimuli (external or internal) that elevate cellular PI5P levels by altering expression of ATX1-controlled genes.
引用
收藏
页码：6049 / 6054
页数：6
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