COVID-19 and multisystem inflammatory syndrome in children and adolescents

被引：539
|
作者：
Jiang, Li [1 ]
Tang, Kun [1 ,3 ]
Levin, Mike [4 ]
Irfan, Omar [1 ]
Morris, Shaun K. [1 ,2 ]
Wilson, Karen [5 ]
Klein, Jonathan D. [6 ]
Bhutta, Zulfiqar A. [1 ,7 ]
机构：
[1] Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON M5G 1X8, Canada
[2] Hosp Sick Children, Div Infect Dis, Toronto, ON, Canada
[3] Tsinghua Univ, Vanke Sch Publ Hlth, Beijing, Peoples R China
[4] Imperial Coll London, Dept Infect Dis, London, England
[5] Mt Sinai Kravis Childrens Hosp, New York, NY USA
[6] Univ Illinois, Dept Pediat, Chicago, IL USA
[7] Aga Khan Univ, Inst Global Hlth & Dev, Karachi 74800, Pakistan
来源：
LANCET INFECTIOUS DISEASES | 2020年 / 20卷 / 11期
关键词：
ANTIBODY-DEPENDENT ENHANCEMENT; NEUTROPHIL EXTRACELLULAR TRAPS; CIRCULATING IMMUNE-COMPLEXES; GENOME-WIDE ASSOCIATION; DISEASE SHOCK SYNDROME; HUMAN CORONAVIRUS NL63; LONG-TERM MANAGEMENT; KAWASAKI-DISEASE; HEALTH-PROFESSIONALS; SARS CORONAVIRUS;
D O I：
10.1016/S1473-3099(20)30651-4
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
As severe acute respiratory syndrome coronavirus 2 continues to spread worldwide, there have been increasing reports from Europe, North America, Asia, and Latin America describing children and adolescents with COVID-19-associated multisystem inflammatory conditions. However, the association between multisystem inflammatory syndrome in children and COVID-19 is still unknown. We review the epidemiology, causes, clinical features, and current treatment protocols for multisystem inflammatory syndrome in children and adolescents associated with COVID-19. We also discuss the possible underlying pathophysiological mechanisms for COVID-19-induced inflammatory processes, which can lead to organ damage in paediatric patients who are severely ill. These insights provide evidence for the need to develop a clear case definition and treatment protocol for this new condition and also shed light on future therapeutic interventions and the potential for vaccine development.
引用
收藏
页码：E276 / E288
页数：13
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